Protein Info for mRNA_5579 in Rhodosporidium toruloides IFO0880

Name: 13947
Annotation: HMMPfam-Zinc-binding dehydrogenase-PF00107,HMMPfam-Alcohol dehydrogenase GroES-like domain-PF08240,SUPERFAMILY--SSF50129,SUPERFAMILY--SSF51735

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08240: ADH_N
  • amino acids 8 to 120 (113 residues), 74.7 bits, E=1.1e-24
• PF01262: AlaDh_PNT_C
  • amino acids 156 to 226 (71 residues), 23.6 bits, E=6.1e-09
• PF00107: ADH_zinc_N
  • amino acids 164 to 291 (128 residues), 49.2 bits, E=1.1e-16

Best Hits

Swiss-Prot: 41% identical to MTDH_MESCR: Probable mannitol dehydrogenase (ELI3) from Mesembryanthemum crystallinum

KEGG orthology group: None (inferred from 49% identity to bfu:BC1G_09005)

Predicted SEED Role

"Alcohol dehydrogenase (EC 1.1.1.1)" in subsystem Fermentations: Mixed acid or Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 1.1.1.1)

MetaCyc Pathways

• 3-methylbutanol biosynthesis (engineered) (6/7 steps found)
• ethanol degradation II (3/3 steps found)
• pyruvate fermentation to ethanol II (2/2 steps found)
• pyruvate fermentation to isobutanol (engineered) (4/5 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• acetaldehyde biosynthesis I (1/1 steps found)
• phytol degradation (3/4 steps found)
• salidroside biosynthesis (3/4 steps found)
• L-isoleucine degradation II (2/3 steps found)
• L-leucine degradation III (2/3 steps found)
• L-methionine degradation III (2/3 steps found)
• L-valine degradation II (2/3 steps found)
• ethanol degradation I (1/2 steps found)
• phenylethanol biosynthesis (3/5 steps found)
• butanol and isobutanol biosynthesis (engineered) (5/8 steps found)
• L-phenylalanine degradation III (2/4 steps found)
• L-tyrosine degradation III (2/4 steps found)
• pyruvate fermentation to ethanol I (1/3 steps found)
• pyruvate fermentation to ethanol III (1/3 steps found)
• (S)-propane-1,2-diol degradation (2/5 steps found)
• acetylene degradation (anaerobic) (2/5 steps found)
• ethanolamine utilization (2/5 steps found)
• cytidine-5'-diphosphate-glycerol biosynthesis (1/4 steps found)
• heterolactic fermentation (11/18 steps found)
• serotonin degradation (3/7 steps found)
• mixed acid fermentation (9/16 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (11/19 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (3/9 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (5/13 steps found)
• superpathway of N-acetylneuraminate degradation (11/22 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (6/17 steps found)
• L-tryptophan degradation V (side chain pathway) (1/13 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• 3-Chloroacrylic acid degradation
• Drug metabolism - cytochrome P450
• Fatty acid metabolism
• Glycine, serine and threonine metabolism
• Glycolysis / Gluconeogenesis
• Metabolism of xenobiotics by cytochrome P450
• Retinol metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.1

Use Curated BLAST to search for 1.1.1.1

Protein Sequence (328 amino acids)

>mRNA_5579 HMMPfam-Zinc-binding dehydrogenase-PF00107,HMMPfam-Alcohol dehydrogenase GroES-like domain-PF08240,SUPERFAMILY--SSF50129,SUPERFAMILY--SSF51735 (Rhodosporidium toruloides IFO0880)
TPKQWTEDDVDIKVDCCGICGSCIHTLTNGWPRPTSYPCIAGHEVVGTIVRAGSRTSHKV
GTRVGVGAQGGSCLECDFCKQGLQQHCDKGMIGTYQGIWEDGSVAQGGYADFMRCRGALA
VPIPDGLESESTAPLLCAGVTVYAPLKRFNAGPGKRVGVIGIGGLGHLALQIAKAMGADV
YALSHSASKMDDAEKLGCPRENFIVAKDQAEVRKKYNKHFDILILTSSANDIPLEGLYLP
LLRNMGTFIICALPEEKLPAMYGQMLVGKSLNLAGSLIGGSSEISELFDLALKHDIKAWV
ETRPMSEATQAAQDMHAGKSRYRYVLKN