Protein Info for mRNA_5654 in Rhodosporidium toruloides IFO0880

Name: 14022
Annotation: K01637 E4.1.3.1, aceA isocitrate lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01346: isocitrate lyase
  • amino acids 17 to 538 (522 residues), 755.4 bits, E=1.4e-231
• PF00463: ICL
  • amino acids 17 to 538 (522 residues), 878 bits, E=1.1e-268

Best Hits

Swiss-Prot: 74% identical to ACEA_COPC7: Isocitrate lyase (ACU-7) from Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)

KEGG orthology group: K01637, isocitrate lyase [EC: 4.1.3.1] (inferred from 74% identity to cci:CC1G_07122)

Predicted SEED Role

"Isocitrate lyase (EC 4.1.3.1), group II (plants and fungi)" (EC 4.1.3.1)

MetaCyc Pathways

• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (22/25 steps found)
• superpathway of glyoxylate cycle and fatty acid degradation (13/14 steps found)
• superpathway of glyoxylate bypass and TCA (11/12 steps found)
• glyoxylate cycle (6/6 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.1.3.1

Use Curated BLAST to search for 4.1.3.1

Protein Sequence (539 amino acids)

>mRNA_5654 K01637 E4.1.3.1, aceA isocitrate lyase (Rhodosporidium toruloides IFO0880)
MVQSFEAQEDQLFKEQVEQVKQWWKSPRFKGLVRPYSAEDVVSKRGTLEIQYPSGVQGKK
LWKMLDQKFKDGLPSHTYGALDPVQVTQMAKYLETVYVSGWQSSSTASSTNEPGPDLADY
PSNTVPNKVEHLFMAQLFHDRKQREARSRMSPEERAKTPYIDYLRPIVADADTGHGGLTA
VMKLTKMFVEKGAAGIHVEDQMPGTKKCGHMAGKVLVPISEHINRLLAIRLQYDIMGVEN
LAVARTDAEAATLLSSNVDERDHPFILGSTNSDLDEDLVTVMSRAERNNVVGEALQKVED
DWTKSANLMLYSDCVAAAAKKKGVSQSKIDEFVKQSAHVSHSKAKKLASQLLGVDPYWNW
DTPRTREGFYRYQGGTQCAINRAVAFAPYCDLLWMETKNPDYKQAKEFAEGVHAVYPDHW
LAYNLSPSFNWSAAGLNEEQMASYVWDLGKLGFCWQFITLAGLHSNAYISDLFAKGFSKE
GMKAYVNIVQSKEREIGCDVLTHQKWSGADYVDNLLKTVTGGISSTAAMGAGVTESQFK