Protein Info for mRNA_5811 in Rhodosporidium toruloides IFO0880

Name: 14179
Annotation: K01599 hemE, UROD uroporphyrinogen decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 49% identical to DCUP_HUMAN: Uroporphyrinogen decarboxylase (UROD) from Homo sapiens

KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 56% identity to scm:SCHCODRAFT_72453)

MetaCyc: 49% identical to Uroporphyrinogen decarboxylase (Homo sapiens)
Uroporphyrinogen decarboxylase. [EC: 4.1.1.37]; 4.1.1.37 [EC: 4.1.1.37]

Predicted SEED Role

"Uroporphyrinogen III decarboxylase (EC 4.1.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.1.1.37)

MetaCyc Pathways

superpathway of heme b biosynthesis from glycine (7/8 steps found)
heme b biosynthesis I (aerobic) (4/4 steps found)
heme b biosynthesis V (aerobic) (3/4 steps found)
superpathway of heme b biosynthesis from glutamate (7/10 steps found)
heme b biosynthesis II (oxygen-independent) (2/4 steps found)
superpathway of heme b biosynthesis from uroporphyrinogen-III (3/6 steps found)
heme b biosynthesis IV (Gram-positive bacteria) (1/5 steps found)
3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (3/9 steps found)
3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (3/9 steps found)
3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (1/9 steps found)
superpathway of bacteriochlorophyll a biosynthesis (4/26 steps found)

KEGG Metabolic Maps

Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.37

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (410 amino acids)

>mRNA_5811 K01599 hemE, UROD uroporphyrinogen decarboxylase (Rhodosporidium toruloides IFO0880)
MTQQEQIDHPVPPSVSEYRFPASFDEFPPLRNDALLQSAQGISPIDLTRPPPIWIMRQAG
RYLPEFQAVRKEHSFFTVCRTPELACEVTLQPIRRYEGLLDASIIFSDILVVPQAMGMEV
QMLGGVGPHFPSPLKNPEDAQTRILDREVDVYEELKYVYAAITKTRHGLEGKVPLIGFCA
GPWTLFGYMVEGGGSRTWEKAKAWAYKSPENAKAVLQKIAEASAEYLVGQVQAGAQLLQV
FDTNADCLTPHGFDTFILPYLALLPILVRSRLASLSIPCPPMTVFAKGATSPAQLSALSQ
IGYQTVGLDWTVTPRYARQHTGSRVALQGNLDPSVLLGGKEAIKREVRNLTWGPDGFLTC
AREGIEGGWIVNLGHGITPGVDPEDARYMLERVRRECAKKSKDDEPDAYA