Protein Info for mRNA_6332 in Rhodosporidium toruloides IFO0880
Name: 14700
Annotation: KOG0725 Reductases with broad range of substrate specificities
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 44% identical to ADRC1_ARATH: NADPH-dependent aldehyde reductase 1, chloroplastic (ChlADR1) from Arabidopsis thaliana
KEGG orthology group: None (inferred from 57% identity to cnb:CNBD4080)MetaCyc: 44% identical to aldehyde reductase (chloroplastic) (Arabidopsis thaliana col)
Aldehyde reductase. [EC: 1.1.1.21]; Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]
Predicted SEED Role
No annotation
MetaCyc Pathways
- L-tryptophan degradation X (mammalian, via tryptamine) (3/4 steps found)
- methylglyoxal degradation III (1/2 steps found)
- glycerol degradation to butanol (11/16 steps found)
- D-galactose degradation IV (1/3 steps found)
- L-arabinose degradation II (1/3 steps found)
- pyruvate fermentation to butanol I (4/8 steps found)
- superpathway of methylglyoxal degradation (4/8 steps found)
- D-xylose degradation to ethylene glycol (engineered) (1/4 steps found)
- detoxification of reactive carbonyls in chloroplasts (4/10 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (5/13 steps found)
- traumatin and (Z)-3-hexen-1-yl acetate biosynthesis (2/9 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (6/17 steps found)
- superpathway of lipoxygenase (3/19 steps found)
- superpathway of pentose and pentitol degradation (6/42 steps found)
KEGG Metabolic Maps
- Caprolactam degradation
- Fructose and mannose metabolism
- Galactose metabolism
- Glycerolipid metabolism
- Glycolysis / Gluconeogenesis
- Pentose and glucuronate interconversions
- Pyruvate metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.2
Use Curated BLAST to search for 1.1.1.2 or 1.1.1.21
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (305 amino acids)
>mRNA_6332 KOG0725 Reductases with broad range of substrate specificities (Rhodosporidium toruloides IFO0880) MGSDAKVITAYPNFSPDKFEQKLPGRDLDMSPLAEHTKVERWHRGEPRLEEYVGSGKLKD KAALITGGDSGIGKTVAVFFAREGADITINYLPEEEDDAQNTKKLVEEAGKKCLLVPGDL RTQEFRDSMIEKHMREYGALDILVNNASQQIQCPDLAEIDMNNVEDTFRCNIIQYIGVSK AALPHMKRGDVIINTTSVTAYKGSAGMLDYSATKGAITTFTKSLATQILPKAIRVVGVAP GPVYTPLQPASRPKEQMEDWSVGSSSLIHGRVAQPAELGESYVYCATSEILTGQVVHPNS GQYLV