Protein Info for mRNA_6435 in Rhodosporidium toruloides IFO0880
Name: 14803
Annotation: K01930 FPGS folylpolyglutamate synthase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Predicted SEED Role
"Dihydrofolate synthase (EC 6.3.2.12) @ Folylpolyglutamate synthase (EC 6.3.2.17)" (EC 6.3.2.12, EC 6.3.2.17)
MetaCyc Pathways
- folate polyglutamylation (5/5 steps found)
- tetrahydrofolate biosynthesis (2/3 steps found)
- superpathway of tetrahydrofolate biosynthesis and salvage (8/12 steps found)
- superpathway of tetrahydrofolate biosynthesis (6/10 steps found)
- superpathway of chorismate metabolism (28/59 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 6.3.2.12, 6.3.2.17
Use Curated BLAST to search for 6.3.2.12 or 6.3.2.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (548 amino acids)
>mRNA_6435 K01930 FPGS folylpolyglutamate synthase (Rhodosporidium toruloides IFO0880) MHASLVRLVARTMSSSAHTGSRSYAAAIDALNGLQSNAQVIDAIRKSGGKGGDVQLREQV EYMRRIGYEPADLNRMNVLHITGTKGKGSTSAFVSSILTTLAPKAKVGLYTSPHMVAVRE RIRINGEPIAEDVFARYFWEVWDRLEQADKPAADEATPEKPAYFRYLTIMAMHVFLSERV DATILEVGVGGTYDSTNIVPEPITTGVTALGIDHIWVLGKTLPEIAAQKGGIYKPRIPAL AIQQPEGLDVLESRAKELGASSFTVIPEHPQLKDIKLGLAGSFQRSNASLAIALVQSFLS SPRCPAALRSLTPPSSPPSSTTSSPLPSLPKSLIAPNPLPSSLVTGLQTARWPGRCQTEP DPLLGGEKVRWFLDGAHTVESLKCCGEWFREDALERTYGTEEQPTRFLIFNCTSGRSGFE LLSSLLSALSPSSAGEKLQQPFDHVVFCTNTTFASGDSKGDLTSNAVDASDLAALQTQHD LASAFSSLTSSPSSSLKQAQIHVLASIQEAVELVRREGQKGEGKSVEALVTGSLHLVGGV MAVAELPL