Protein Info for mRNA_6588 in Rhodosporidium toruloides IFO0880

Name: 14956
Annotation: K00966 GMPP mannose-1-phosphate guanylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 368 PF00483: NTP_transferase" amino acids 6 to 233 (228 residues), 171.6 bits, see alignment E=3.7e-54 PF12804: NTP_transf_3" amino acids 7 to 115 (109 residues), 33.4 bits, see alignment E=8.9e-12 PF00132: Hexapep" amino acids 261 to 294 (34 residues), 26.5 bits, see alignment 6e-10

Best Hits

Swiss-Prot: 72% identical to MPG1_CRYNJ: Mannose-1-phosphate guanyltransferase (MPG1) from Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)

KEGG orthology group: K00966, mannose-1-phosphate guanylyltransferase [EC: 2.7.7.13] (inferred from 72% identity to cne:CNC03020)

MetaCyc: 59% identical to GDP-D-mannose pyrophosphorylase (Arabidopsis thaliana col)
Mannose-1-phosphate guanylyltransferase. [EC: 2.7.7.13]

Predicted SEED Role

"Mannose-1-phosphate guanylyltransferase (EC 2.7.7.13 )" in subsystem Mannose Metabolism

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (368 amino acids)

>mRNA_6588 K00966 GMPP mannose-1-phosphate guanylyltransferase (Rhodosporidium toruloides IFO0880)
MPGDLKALILVGGFGTRLRPLTLTYPKPLVPFANKAIILHLVENLVKAGVKHIVLAVNYR
PEVMISVLKQYEEKYNITITFSVENEPLGTAGPLALARDVLGKDDAPFFVLNSDVTCSYP
FEELRDFHLAHGGEGTIMVTKVDEPSKYGVVLTVPGQSTIDRFVEKPKEYVGNRINAGIY
IFNPSILDRIEVKPTSIESEIFPAMARDRQLHSMDLEGFWMDIGQPKDYLTGTCLYLSYL
TSKKSPELADPAKHDAVVAGNVIIHPTATVDPTAVIGPNVIVGPNCQVGAGARLQRCVLL
DGARVKAHAFVQSSIIGWSSSVGRWARVEGTTVLGDDVAVKDEVYVNGASVLPHKSLSSS
IYEPSIVM