Protein Info for mRNA_6850 in Rhodosporidium toruloides IFO0880

Name: 15218
Annotation: K05605 HIBCH 3-hydroxyisobutyryl-CoA hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF16113: ECH_2
  • amino acids 63 to 310 (248 residues), 273.4 bits, E=3.7e-85
  • amino acids 333 to 436 (104 residues), 75.9 bits, E=4.3e-25
• PF00378: ECH_1
  • amino acids 64 to 248 (185 residues), 85.8 bits, E=3e-28

Predicted SEED Role

"3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)" in subsystem Isobutyryl-CoA to Propionyl-CoA Module or Valine degradation (EC 3.1.2.4)

MetaCyc Pathways

• L-valine degradation I (6/8 steps found)
• propanoyl-CoA degradation II (3/5 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (5/10 steps found)
• β-alanine biosynthesis II (1/6 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.2.4

Protein Sequence (541 amino acids)

>mRNA_6850 K05605 HIBCH 3-hydroxyisobutyryl-CoA hydrolase (Rhodosporidium toruloides IFO0880)
MLCATARPRLALVNTRTVAMSTPAKRSQMVANHLASRNAHSQHPKPIAHNDKPVVVEALH
AMRKLVLNRPKALNSLNEEMIDLIQTNLTKLEKSELANVILIKSNGKHFCAGGDVVTLSK
YLEDEKTWVKASSFFEKEYETNHFLATTPKPVVAIMNGVTFGGGVGITGHGAFRIATETT
QIAMPETKIGLFPDVGANFILPRLDGQLGLYLGLTSFPLKGAATYLAGLATHYVPSDRLA
DLEHRLSELDVTATHETVNACIEEFVADSDELRNALEAYPLVGAIRRAIDDTFARKTPEE
MVSELAKMYEKERPDDPDCPLPDVSRFTGHSDLEAADAMELRRWAQETREAIELRSPTSV
KLTIQAIRQGRNLTIDDVFKMDARIAAACCSPSVHPDFRHGVTELLIKKNKPEIKRPDWH
PATLSEVTDDHIQKTFFAHPPPFTNPPLPKLNFSRMQRAQGAYPTYRVSPHAKWLLPTER
DVEKVVKGEDAGSDEYAVTKQEVVERLVARWRGKVGVAEKVEEVLSRKTVVAEQDTLKWV
S