Protein Info for mRNA_7137 in Rhodosporidium toruloides IFO0880

Name: 15505
Annotation: KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1398 transmembrane" amino acids 55 to 76 (22 residues), see Phobius details amino acids 357 to 374 (18 residues), see Phobius details amino acids 384 to 408 (25 residues), see Phobius details amino acids 415 to 438 (24 residues), see Phobius details amino acids 459 to 482 (24 residues), see Phobius details amino acids 488 to 511 (24 residues), see Phobius details amino acids 572 to 589 (18 residues), see Phobius details amino acids 699 to 721 (23 residues), see Phobius details PF12349: Sterol-sensing" amino acids 380 to 521 (142 residues), 100 bits, see alignment E=1.2e-32 PF02460: Patched" amino acids 380 to 514 (135 residues), 27.7 bits, see alignment E=7.8e-11

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1398 amino acids)

>mRNA_7137 KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) (Rhodosporidium toruloides IFO0880)
MASVGIRSRAKRRPSAPSPAVASSLGGWQYVGTVHAKLADWFAWLGVWISQHQTLSLLAT
ALVICSLLSPAILLTFSPSGSIFDISTSAITRRGRGELIWELDGMKRQGLISTEEEVCWD
RVKAFYEKTGREGGGRRIRVAQVLVGAGAVGGRGTISKVVLHRTWRVQEELERRLLAGEI
EGNRCLRTKEGGSSRCAVISPVGWWNSEDELLRDDDVHRTLSLPPRPKTESRALPLTTSQ
TFVGVGRDRHGLVKSAQQLVVNFLFDDGPIAAPLVSSSLPGINSTVAENAARAAASSAWR
KAVQEVVDRKDQRSSATGRAADPMGVTTENRMPPRHIVLKYLPHLTVAGHHRRLENLIYG
VGYLLVALYVWRYIRKLRAHSKLGLLVTGCVELAASGIMSVSICWLLGWSLGLVPWNLLA
FLVLTSGLDNMILVLRSIASTDVNLPVPQRMSIGLRSVGVEMTVLLAVEELMALLLLCWV
QISVMREWIRFGAVVLVVDYFLEITFFSTVLSIDIQRLELADLLAQNPSSGYQAVHSSVQ
GEKGRKGASTTASVGASVKSAWKVLRDRPAKTSTVAFLWAINLLLWAFYGSEHYLPAVCS
QTALSSDRPFLAPSLAPDITRSLRLGQTSDPSSSSYLDIPAGAASAFWQLVNPSNATSVQ
VYLEPTVSIQFFDEDILAAPESIDLLFPTDSAPSLVTKVGLVLLPIAVVMGLLYLLLLYL
LKDAELLQAHWGSEGRLGGPSSRRRRKQEAEKRPDAGVEVVKQMSSRHINDVELIASGGD
VVASWAALEDCILVKQRHGAAVTLDIPVEAEPAVLSSLVVDPTGRFCAAATATGRLHVWS
IEDGGAPLVLNSTRSTQSPVIALAERGSTSQSGAGLANGSTMPSVNSFVGAGNFDANEQA
VFFALHRDEAVTGWTPSTGESIVVAPSDSQQDGSTQTSFIAATSAGSASTTPLLAKTSQD
GHLQLVTIDGAERTVFRESVGRPGARLTALAVSQADAGVLATGYSDGHVVFRSLASPSDP
IAETHAVDGPVRQFRLLAAPERQTCSDCGEQVDDGFVAVVTDRSTLKVLRVYTPSTTAAV
EPCKCNTDDVAAIARSRSSSMGVGSPAMARTLSNGISRRFSPRKKPPTPIRPQQPSLLGD
SPIRPRARQYASNGSSSSSNSSSPTRDRSLNGLSMLGSPAPPPPMATSPTVSQPSSPRSS
TVPLVPDTDTIASLDSISSSSTPSMRCVEFARMPLDDRGGWEVMAGRLVGFRRARPLEAA
SQRGWEVWTLELGRAGTPYDEGYEEGTASLADLLQTEREEDRGSVATQSIMPPATFRQRR
PSAVHALRSPRASLSTTRPSSIRFAENTPDLPFSRARPVVSALDGKAVSVALGNRVVVLR
SAKKQSDGVAQRNGFLGL