Protein Info for mRNA_7325 in Rhodosporidium toruloides IFO0880

Name: 15693
Annotation: K01640 E4.1.3.4, HMGCL, hmgL hydroxymethylglutaryl-CoA lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00682: HMGL-like
  • amino acids 28 to 304 (277 residues), 124.5 bits, E=3e-40

Predicted SEED Role

"Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism (EC 4.1.3.4)

MetaCyc Pathways

• L-leucine degradation I (5/6 steps found)
• mevalonate degradation (1/2 steps found)
• ketogenesis (3/5 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Synthesis and degradation of ketone bodies
• Valine, leucine and isoleucine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.4

Protein Sequence (353 amino acids)

>mRNA_7325 K01640 E4.1.3.4, HMGCL, hmgL hydroxymethylglutaryl-CoA lyase (Rhodosporidium toruloides IFO0880)
MLTRALRHPRGLPSFSRALSSSSSQQPIKLVEVGPRDGLQNEKTPLDAQIKVELIERLVR
SGLRDVEAGSFVSPKWVPQMATTPEVLTSPTLAQLRRDYPDLSLPVLVPNARGLSSLTTL
LSQHPSDPPLTNEIAVFVAASEGFSRANLNTTVADSLASLPPIFDSAKKQGLRVRAYVSV
VLGCPFDGRIEPEKVAGVAKELLEMGAYEVSLGDTIGVGVPAGWEKLLNECERKGVPVSK
LAAHCHDTYGTAISNILHCVSLGIPTVDTSIASLGGCPYSPGATGNVSTEDVLYALYHSG
IPSSFERLCAVGEWVSERLGRANGSSVGRAVRGEREREEKRKAKEAEKQKAKL