Protein Info for mRNA_7338 in Rhodosporidium toruloides IFO0880

Name: 15706
Annotation: K00451 HGD, hmgA homogentisate 1,2-dioxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 509 TIGR01015: homogentisate 1,2-dioxygenase" amino acids 25 to 457 (433 residues), 561 bits, see alignment E=7.7e-173 PF04209: HgmA" amino acids 26 to 457 (432 residues), 563.2 bits, see alignment E=1.7e-173

Best Hits

Swiss-Prot: 49% identical to HGD_BURP0: Homogentisate 1,2-dioxygenase (hmgA) from Burkholderia pseudomallei (strain 1106a)

KEGG orthology group: None (inferred from 64% identity to ang:ANI_1_60094)

Predicted SEED Role

"Homogentisate 1,2-dioxygenase (EC 1.13.11.5)" in subsystem Homogentisate pathway of aromatic compound degradation (EC 1.13.11.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.13.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (509 amino acids)

>mRNA_7338 K00451 HGD, hmgA homogentisate 1,2-dioxygenase (Rhodosporidium toruloides IFO0880)
MSTTATAQGAYAIHPLKAGRAADPYTYQVGFGNAFASEAVPETLPVGQNSPQKNKFGLYA
EQVTATSFVAPRHSNQKLWLYRMRPSVAHQGFVRIPDNKDLCSEFSTSNPRCSVSPTQIA
WRPFPLPKDSEKVNFVQGMKTVAGQGSPESASGLAIHMYLANSSMDKEAFINNDGDMLIV
PQQGRLDIQTELGHLMVSPGEICVIQRGLRFKVKLPDGPSRGYIQEIFGTHYKLPELGPL
GANGLANPRDFEHPVASFEIDQSGWLITYKLMGTLWACSQEHSPFDVVAWHGNYVPYKYD
LSRFCGVGSITFDHIDPSIFCVLTADSDTPGTPLADFLLFHPRWDVASHTFRPPYMHRNA
ASEVMALIKGGYGGRSDDFQPGGMSYECGFTPHGVDYETWKAATEMSQEGAQWISDGTYA
VMFETSRMLLLTDYATERAGTIHYHEPKMWDPLEAEFIERLSEVNEHLAKHGLPALSAGN
ATRGNQGLPRRTVEGESAMEGSEEHANGH