Protein Info for mRNA_7446 in Rhodosporidium toruloides IFO0880
Name: 15814
Annotation: K14085 ALDH7A1 aldehyde dehydrogenase family 7 member A1
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 52% identical to AL7A1_PEA: Aldehyde dehydrogenase family 7 member A1 from Pisum sativum
KEGG orthology group: K14085, aldehyde dehydrogenase family 7 member A1 [EC: 1.2.1.3 1.2.1.31 1.2.1.8] (inferred from 56% identity to cnb:CNBA6940)MetaCyc: 54% identical to Alpha-aminoadipic semialdehyde dehydrogenase (Homo sapiens)
Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]; L-aminoadipate-semialdehyde dehydrogenase. [EC: 1.2.1.8, 1.2.1.31]
Predicted SEED Role
"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)
MetaCyc Pathways
- choline-O-sulfate degradation (3/3 steps found)
- ethanol degradation II (3/3 steps found)
- ethanol degradation IV (3/3 steps found)
- choline degradation I (2/2 steps found)
- glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
- glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (3/4 steps found)
- phytol degradation (3/4 steps found)
- L-lysine degradation VI (2/3 steps found)
- ethanol degradation III (2/3 steps found)
- glycine betaine biosynthesis III (plants) (2/3 steps found)
- hypotaurine degradation (2/3 steps found)
- methylglyoxal degradation V (2/3 steps found)
- β-alanine biosynthesis I (1/2 steps found)
- β-alanine biosynthesis IV (1/2 steps found)
- L-lactaldehyde degradation (aerobic) (1/2 steps found)
- L-lysine degradation IX (1/2 steps found)
- L-lysine degradation VIII (1/2 steps found)
- L-lysine degradation XI (mammalian) (3/5 steps found)
- choline degradation IV (2/4 steps found)
- fatty acid α-oxidation I (plants) (2/4 steps found)
- dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
- histamine degradation (1/3 steps found)
- methylglyoxal degradation IV (1/3 steps found)
- 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
- lactate biosynthesis (archaea) (2/5 steps found)
- mitochondrial NADPH production (yeast) (2/5 steps found)
- octane oxidation (2/5 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (4/8 steps found)
- superpathway of methylglyoxal degradation (4/8 steps found)
- dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)
- putrescine degradation III (1/4 steps found)
- serotonin degradation (3/7 steps found)
- dopamine degradation (1/5 steps found)
- ceramide degradation by α-oxidation (2/7 steps found)
- limonene degradation IV (anaerobic) (2/7 steps found)
- sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
- alkane oxidation (1/6 steps found)
- L-lysine degradation V (3/9 steps found)
- L-rhamnose degradation II (2/8 steps found)
- aromatic biogenic amine degradation (bacteria) (2/8 steps found)
- L-lysine degradation II (L-pipecolate pathway) (2/9 steps found)
- noradrenaline and adrenaline degradation (4/13 steps found)
- ceramide and sphingolipid recycling and degradation (yeast) (6/16 steps found)
- superpathway of fucose and rhamnose degradation (2/12 steps found)
- superpathway of L-lysine degradation (11/43 steps found)
KEGG Metabolic Maps
- 1,2-Dichloroethane degradation
- 3-Chloroacrylic acid degradation
- Arginine and proline metabolism
- Ascorbate and aldarate metabolism
- Butanoate metabolism
- Fatty acid metabolism
- Glycerolipid metabolism
- Glycine, serine and threonine metabolism
- Glycolysis / Gluconeogenesis
- Histidine metabolism
- Limonene and pinene degradation
- Lysine biosynthesis
- Lysine degradation
- Propanoate metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.3, 1.2.1.31
Use Curated BLAST to search for 1.2.1.22 or 1.2.1.3 or 1.2.1.31 or 1.2.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (540 amino acids)
>mRNA_7446 K14085 ALDH7A1 aldehyde dehydrogenase family 7 member A1 (Rhodosporidium toruloides IFO0880) MLRFTTLRTAARPLVHSRALSSRASSVLSSLDLPTSGQPINGVFYDAAVGWTGSGEVQRS TNPATGEVLAEVRTASKEDVDKVLKASRRAYESWRTVPAPKRGEALRQIRVAMNERIEDL GKLVSLEMGKVLSEGRGEVQEFVDEMDLAVGLSRSIGGTVVPSERGRHFITEVANPLGVV GVITAFNFPSAVFGWNFSLSFITGNATVWKPAPTTPLTAIASTKIIQEVLAANKLDGALA ALVCGGGEAGEALVTDKQVDLLSFTGSEARGRDVSMKVASRFGQSLLELGGNNAAIVLPD ANLPLALRAVTFAALGTSGQRCTSTRRLFLHSSIASHFISSLTAAYKSISPSRMGDPLDG KTLVGPLHTRDSVKRFEQAVKTAKEQGGEVLVGGNVVEMQGDLAGGNWVEPTIVLVKDVN QVAIMKQETFAPILYVSAFESLEEAIALNNSVEQGLSMSLFTKDLGAAMQVIGPAGADSG IINVNSSTSGAEIGAPFGGNKSTGWGRESGGDAWKRYCRWSSCTLNYSDELGLAQGVTFD