Protein Info for mRNA_7496 in Rhodosporidium toruloides IFO0880

Name: 15864
Annotation: K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01962: NADH dehydrogenase (quinone), D subunit
  • amino acids 90 to 473 (384 residues), 587.5 bits, E=5.5e-181
• PF00346: Complex1_49kDa
  • amino acids 203 to 473 (271 residues), 408.1 bits, E=7.3e-127

Best Hits

Swiss-Prot: 77% identical to NDUS2_NEUCR: NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial (nuo-49) from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

KEGG orthology group: K03935, NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC: 1.6.5.3 1.6.99.3] (inferred from 83% identity to cnb:CNBL2770)

MetaCyc: 76% identical to NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (Homo sapiens)
NADH-DEHYDROG-A-RXN [EC: 7.1.1.2]

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain D (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration I (cytochrome c) (3/4 steps found)
• aerobic respiration III (alternative oxidase pathway) (2/3 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• Fe(II) oxidation (2/6 steps found)
• NAD(P)/NADPH interconversion (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3, 1.6.99.3

Use Curated BLAST to search for 1.6.5.3 or 1.6.99.3 or 7.1.1.2

Protein Sequence (473 amino acids)

>mRNA_7496 K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 (Rhodosporidium toruloides IFO0880)
MAGGELSPILLLLLPSALTSTQTGLTMLRSALPRLRTFAQPSARIASRTLATEATPSPRR
HQTFVEDVHNQTAAEILKERDDKSGSFRAFTLNFGPQHPAAHGVLRLILELNGEEVLRAD
PHIGLLHRGTEKLIEFKNYTQALPYFDRLDYVSMMTNELCYSRAVETLLNIEVPERAKWI
RTLFGEITRILNHLMAVLTHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPG
GVAYDLPHGLLEDIYKWATAFSQRVDEVEEVLTGNRIWKQRTIGIGPVTAQQALDYSFSG
VMLRGSGIPWDIRKVQPYDAYDKVEFDIPVGKNGDCYDRYLCRIEEFRQSLRIINQCLDK
MPPGQIKVDDHKIVPPPRASMKESMESLIHHFKLFSEGYSVPPGETYAPIEAPKGEMGVY
LVSDGTNRPYRCKIRAPGFAHLAGADFMSRGCFLPDVVAIIGTMDLVFGEVDR