Protein Info for mRNA_7532 in Rhodosporidium toruloides IFO0880

Name: 15900
Annotation: K01896 ACSM medium-chain acyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 32 to 457 (426 residues), 260.8 bits, E=1.9e-81
• PF13193: AMP-binding_C
  • amino acids 467 to 553 (87 residues), 67.7 bits, E=1.4e-22

Predicted SEED Role

"Acetyl-coenzyme A synthetase (EC 6.2.1.1)" in subsystem Ketoisovalerate oxidoreductase or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 6.2.1.1)

MetaCyc Pathways

• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• acetate conversion to acetyl-CoA (1/1 steps found)
• chitin deacetylation (3/4 steps found)
• L-isoleucine biosynthesis V (2/3 steps found)
• ethanol degradation III (2/3 steps found)
• superpathway of acetate utilization and formation (2/3 steps found)
• reductive glycine pathway (6/9 steps found)
• adlupulone and adhumulone biosynthesis (1/6 steps found)
• colupulone and cohumulone biosynthesis (1/6 steps found)
• lupulone and humulone biosynthesis (1/6 steps found)
• cis-geranyl-CoA degradation (1/9 steps found)
• superpathway of bitter acids biosynthesis (3/18 steps found)

KEGG Metabolic Maps

• Glycolysis / Gluconeogenesis
• Propanoate metabolism
• Pyruvate metabolism
• Reductive carboxylate cycle (CO2 fixation)

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.1

Use Curated BLAST to search for 6.2.1.1

Protein Sequence (578 amino acids)

>mRNA_7532 K01896 ACSM medium-chain acyl-CoA synthetase (Rhodosporidium toruloides IFO0880)
MASEFSYDAIHARYGDGIPCPPDYSFPTHVIDRWAREQPDRPAIHWVSHDFKKERIMSYR
ELADASNKAAKAFQDKGLKKGDRALIQLPRVCEWFVAVLGLWRIGAVASPSTSLLVSKDL
KFRAEVAKAKAFIGDHESCGRFEEISSTVGISLIFQVRTDDDGGLGAGRVDFQDALSKVP
DGTKCEAPGGHNSTDLVILFFTSGTTGAPKMVLLEAEYLVGHTITGLWYQAKPGTLVLCM
ADLGWAKGTYGGAGAFSMGATVFLQPPPPGNFTPTHLINALHRYPIETLCAPPTIYRSLV
TSSARAYLKKNPLKALRHCVGAGEPLNASVIKEWREITGNLTIRDGWGMSETVIAVGNFE
GVELRQGSMGKPAPFFQMGIVGHNGEELRDGEEGELAIRTDKGAGSCWIFKGYVKNGKVD
KRQKSHGGKTWFCTGDRGMRDADGYYWFVGRDDDVITSSGYRIGPFEVESALKTHPAVVE
SAAVGSPDLSRGEVVKAFVILSDEYRDKVLGKKDKEKDLILDMQNHFKKMTAPYKVPREI
EFVDTLPKTVSGKIRRIELRDLEKQRKADIVKQQKAKL