Protein Info for mRNA_7874 in Rhodosporidium toruloides IFO0880

Name: 16242
Annotation: K02202 CDK7 cyclin-dependent kinase 7

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 361 PF00069: Pkinase" amino acids 15 to 295 (281 residues), 243.4 bits, see alignment E=2.9e-76 PF07714: Pkinase_Tyr" amino acids 17 to 211 (195 residues), 101.9 bits, see alignment E=3.8e-33

Best Hits

Swiss-Prot: 49% identical to CDKD2_ARATH: Cyclin-dependent kinase D-2 (CDKD-2) from Arabidopsis thaliana

KEGG orthology group: K02202, cyclin-dependent kinase 7 [EC: 2.7.11.22] (inferred from 66% identity to cci:CC1G_00997)

Predicted SEED Role

"Transcription initiation factor IIH cyclin-dependent kinase 7" in subsystem RNA polymerase II initiation factors

Isozymes

Compare fitness of predicted isozymes for: 2.7.11.22

Use Curated BLAST to search for 2.7.11.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (361 amino acids)

>mRNA_7874 K02202 CDK7 cyclin-dependent kinase 7 (Rhodosporidium toruloides IFO0880)
MEAAEAANAAIQRKYTKDKKVGEGTYAVVYVGKEVATARKIAIKKIKVGQFKDGLDMSAI
REVKFLRELRHPNVIELLDVFSNKSNLNLVLEFLDTDLEAVIRDKALVFQGADVKSWMLM
TMKGLDFCHTNWILHRDMKPNNLLISADGVLKLADFGLAREYADEGARMTCQVVTRWYRC
PELLLGARSYSTGVDVWAAGCIFAELMLRVPFMAAESDMEQLNMIFSALGTPTEADWPGF
GKLSNGASFEKKPKNDLSMLFSAASPEAIDLLQRMLTYDPRRRITARESLHHPFFHSQPR
PTPPSKLPKPTAELAPRALPPEEIGAPMDSKERRGTKRKGDGYDEIPGAKKVARKLDFGT
A