Protein Info for mRNA_7905 in Rhodosporidium toruloides IFO0880

Name: 16273
Annotation: K00147 proA glutamate-5-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 9 to 294 (286 residues), 46.9 bits, E=7.9e-17
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 25 to 425 (401 residues), 482.3 bits, E=5.2e-149

Best Hits

Swiss-Prot: 56% identical to PROA_SCHPO: Probable gamma-glutamyl phosphate reductase (pro1) from Schizosaccharomyces pombe (strain 972 / ATCC 24843)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 64% identity to scm:SCHCODRAFT_54944)

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• superpathway of L-citrulline metabolism (10/12 steps found)
• L-citrulline biosynthesis (7/8 steps found)
• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (3/4 steps found)
• L-N^δ-acetylornithine biosynthesis (5/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Protein Sequence (462 amino acids)

>mRNA_7905 K00147 proA glutamate-5-semialdehyde dehydrogenase (Rhodosporidium toruloides IFO0880)
MSSNGAAPTAGQVARTAKETFDASQLLDSSERHTALLALKQALTDAKEEILQANRQDIEA
AREQVAAGKMSSSLLKRLDLQSSADKYDSMLQGILDVDSLPDPTGQVTYARKLDEGLDLY
RVTCPIGVLLVIFEARPEVIVNITALAIKSGNAAILKGGKESIHTQNVMTRVIQSALSTT
SLPPAYIQTVSSRSEIASLLSQDRYIDLVIPRGSNSLVRSIQNGTRIPVMGHADGLCAVF
VDESAVEKKAINVVVDSKTTYTAACNAAETLLIHDSLLSSLWPRLASALLDANIQLRCDP
STLSALSSSIFSHPSFSTLVKPSTDEDYETEFLDLILAVKAVPSCAAAISHINNHSSHHT
DAIVTEDEANARAFCRGIDSAGVYVNASTRFADGFRYGFGTEVGVSTGKTHARGPVGLEG
LVIYKYQIKSTAAEGHGTAVFGSGEGKKPFLHTPLPLDKPAY