Protein Info for mRNA_8239 in Rhodosporidium toruloides IFO0880

Name: 16607
Annotation: K00101 E1.1.2.3, lldD L-lactate dehydrogenase (cytochrome)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 515 PF00173: Cyt-b5" amino acids 13 to 83 (71 residues), 68 bits, see alignment E=1e-22 PF01070: FMN_dh" amino acids 125 to 469 (345 residues), 394.4 bits, see alignment E=6.7e-122 PF01645: Glu_synthase" amino acids 377 to 428 (52 residues), 22.7 bits, see alignment 8e-09

Best Hits

Swiss-Prot: 59% identical to CYB2_WICAO: Cytochrome b2, mitochondrial (CYB2) from Wickerhamomyces anomalus

KEGG orthology group: K00101, L-lactate dehydrogenase (cytochrome) [EC: 1.1.2.3] (inferred from 67% identity to scm:SCHCODRAFT_57415)

Predicted SEED Role

"L-lactate dehydrogenase (EC 1.1.2.3)" in subsystem L-rhamnose utilization or Lactate utilization or Respiratory dehydrogenases 1 (EC 1.1.2.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.2.3

Use Curated BLAST to search for 1.1.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (515 amino acids)

>mRNA_8239 K00101 E1.1.2.3, lldD L-lactate dehydrogenase (cytochrome) (Rhodosporidium toruloides IFO0880)
MSSDADKRPLHHSEVAKHADKDSLWVIVNGNAYDLTEFAPEHPGGMGILLKYAGKDATEA
YEPIHPPGTLEQYLPKDKHLGPVDLSGLEIVAKEETQEEKDRKKRAEEKPPMDECLSLYD
FEAVAKSVLPVGAWAYYSSGADDEITMRENRNAYQRIWFRPRILRDVTTIDFSSTILGHK
TSLPIYITATALGKLGHPEGEKNLTWAAHEQGVIQMIPTLASCSFDEIVDAAKPGQVQFM
QLYVNKDREITRKIVQHAEKRGIKGLFITVDAPQLGRREKDMRQKFADEGSNVQRTQGES
VDKTQGAARAISSFIDPGLSWKDIPWFKSITKMPIILKGVQCWEDAVLAAEQGLAGVVLS
NHGGRQLDFARSGIEILEEVMRELRKRDLLKNGFEVYIDGGVRRAGDVLKAIALGAKAVG
IGRPFLYAYSAYGHEGVIKAIQILKDEMEMNMRLIGAPTIQDVTPEMIDTSGLSNRLVDG
ASDYLMRANYEPLAGVGNGLGAQPRLISKETKASL