Protein Info for mRNA_8262 in Rhodosporidium toruloides IFO0880

Name: 16630
Annotation: K01958 PC, pyc pyruvate carboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1190 PF00289: Biotin_carb_N" amino acids 38 to 147 (110 residues), 137.1 bits, see alignment E=1.9e-43 TIGR01235: pyruvate carboxylase" amino acids 40 to 1187 (1148 residues), 1754 bits, see alignment E=0 PF02786: CPSase_L_D2" amino acids 152 to 359 (208 residues), 263.5 bits, see alignment E=7.2e-82 PF02222: ATP-grasp" amino acids 174 to 328 (155 residues), 31.2 bits, see alignment E=9e-11 PF07478: Dala_Dala_lig_C" amino acids 181 to 327 (147 residues), 37.7 bits, see alignment E=8.9e-13 PF02655: ATP-grasp_3" amino acids 185 to 330 (146 residues), 38.1 bits, see alignment E=9e-13 PF02785: Biotin_carb_C" amino acids 375 to 482 (108 residues), 105.1 bits, see alignment E=1.2e-33 PF00682: HMGL-like" amino acids 574 to 845 (272 residues), 97.3 bits, see alignment E=6.7e-31 PF02436: PYC_OADA" amino acids 871 to 1071 (201 residues), 232.1 bits, see alignment E=2.9e-72 PF00364: Biotin_lipoyl" amino acids 1121 to 1187 (67 residues), 60.9 bits, see alignment 4.7e-20 PF13533: Biotin_lipoyl_2" amino acids 1121 to 1149 (29 residues), 25.8 bits, see alignment (E = 4.2e-09) amino acids 1158 to 1187 (30 residues), 23.6 bits, see alignment (E = 2e-08)

Best Hits

Swiss-Prot: 65% identical to PYC_ASPTE: Pyruvate carboxylase (pyc) from Aspergillus terreus

KEGG orthology group: K01958, pyruvate carboxylase [EC: 6.4.1.1] (inferred from 65% identity to ani:AN4462.2)

MetaCyc: 65% identical to pyruvate carboxylase monomer (Aspergillus terreus)
Pyruvate carboxylase. [EC: 6.4.1.1]

Predicted SEED Role

"Pyruvate carboxylase (EC 6.4.1.1)" (EC 6.4.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.4.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1190 amino acids)

>mRNA_8262 K01958 PC, pyc pyruvate carboxylase (Rhodosporidium toruloides IFO0880)
MSRDVTALKTPMPSRPESPGAMTPSINSLRRLGRSQPLRKILVANRGEIAIRVFRTAHEL
GMTTVAIYSHEDRFSAHRNKADEAYMVGKGMTPVAAYLAQDDIIRVALEHGVTMIHPGYG
FLSENAEFARKVEEAGLIFVGPQPSVIDGLGDKVKARALAMSIQVPVVPGTPGAIENFKE
ADAFVAEHGFPVIIKAAMGGGGRGMRVVREASEFESAFKTAVSEAKSAFGDGTVFVERFL
DHPRHIEAQLIGDSEGNVVHLFERDCSVQRRHQKVVELGPSTNLPDELREQLLADAVKIC
KAVGYRNAGTCEFLVDSRGYYFIEINPRIQVEHTVTEEITGIDIVAAQIQIAAGATLAEL
GLTQDTITKRGYAIQCRITTEDPASGFQPDTGKIEVYRSAGGNGVRLDASSGFAGAQITP
HYDSLLVKCTTRGATFEIARRKMLRALVEYRIRGVRTNIPFLFRVLSHPAFVEGRTWTTF
IDDTPELFNLVNSQNRAQKLLSYLGDLAVNGSSIKGQQGEPGLHEEIPIPTFYDSKDDSK
PIDTSAPCQTGWRNIIQEKGPEGFAKAVREYPGVLIMDTTWRDAHQSLLATRLRTIDMAN
IAKETSHALQNAYSLECWGGATFDVAMRFLYEDPWERLRELRKLVPNIPFQALVRGANAV
GYTSYPDNAIYEFSKRAVENGLDIFRVFDSLNYIENMRLGIDAAKQAGGVVEAVICYTGD
VANPKGHSKYTLDYYLNFAQELVDCGIHVLAIKDMAGLLKPEAATMLVGALRKKFPDIPI
HVHSHDTAGISVSSMLACAAAGADVIDVAIDSMSGTTSQPSMGAVCSALEQSGLGTGISY
ANIQALNLYWSNVRQLYQCFEANVRASDSGVFEHQMPGGQYTNLMFQSQQLGLSGQWKAV
VKAYIEANELCGDIVKVTPSSKVVGDFAQFLVANKLSKQDILDQADKLDFPSSVVEFFQG
YLGQPVGGFPEPLRSKIIRDKERIDGRPGQNMKPYPFAEVRQQLVDKYGSTISSCDVLSY
CMYPKVFEEFKEFNLKYGELSKLPTRYFLAKPPIGEEVQVEIEQGKMLIIKLIAVSPVNP
VTGIREVLFELNGEARLVKIEDRNAAIETVRREKATKEPGSIGASMSGVVVEIRVKEGQD
VKAGDPVAVMSAMKMESNVSSPVSGKVKRVAVQAGDSLDQGDLILEIVHS