Protein Info for mRNA_309 in Rhodosporidium toruloides IFO0880

Name: 8677
Annotation: K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01821: 5-aminolevulinic acid synthase
  • amino acids 168 to 578 (411 residues), 624.4 bits, E=3.9e-192
• PF00155: Aminotran_1_2
  • amino acids 216 to 567 (352 residues), 256.2 bits, E=5.8e-80
• PF00266: Aminotran_5
  • amino acids 294 to 384 (91 residues), 23.3 bits, E=3.1e-09

Predicted SEED Role

"5-aminolevulinate synthase (EC 2.3.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 2.3.1.37)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glycine (7/8 steps found)
• tetrapyrrole biosynthesis II (from glycine) (3/4 steps found)
• 2-amino-3-hydroxycyclopent-2-enone biosynthesis (2/4 steps found)
• superpathway of bacteriochlorophyll a biosynthesis (4/26 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.37

Protein Sequence (646 amino acids)

>mRNA_309 K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase (Rhodosporidium toruloides IFO0880)
MAYEVAQALKRYGAVCPFLSHASVSSLRQYSTQSLRGTYTNRLTELASTRCPLMSHALAE
RGFATSAVVPARQQQPATTNQATPKSSSALAHSPSPAALARGYASIAEVQENAIRRATET
SQAPQPAFVNPASISRDAHSPNEVHSAGRPTCALGFAKHRITSFRPGFDYEAFYGGELAK
KHQDKSYRYFNNVNRLAAKYPVAHTANKADEVTVHCSNDYLGMGRHPVTLKAIHETLDTY
GAGAGGTRNIAGNGAMHLALEAELASLHQKPAALVFSSCYVANVETLSTLGSKLPGCVIL
SDEMNHASMIQGIRHSRAQKMIFKHNDLVDLENKLKALPLETPKIIAFESVYSMSGTVGP
IKEICDLAEKYGAITFLDEVHAVGMYGPTGAGVAEHLDFYANARGGEQGSVMDRVDIITG
TLGKAYGVVGGYIAGSSQFVDMVRSYAPGFIFTTSIPPSTAAGARAAIAYQKEHLGDRQL
QQRNVARVKRDLTAIGIPVIPNPSHIVPLLVGDADLAKQASDLLLTKHKLYIQSINFPTV
SRGEERLRITPSPLHTDAQLKDLVAALDSVWNELGLKRTSEWEAEGGRCGVGIKEPKEVV
NLWTEDLLALKDVDDARDKAVAMQGATFADAQDSAVKSKVAASASA