Protein Info for mRNA_334 in Rhodosporidium toruloides IFO0880

Name: 8702
Annotation: K00938 E2.7.4.2, mvaK2 phosphomevalonate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00288: GHMP_kinases_N
  • amino acids 150 to 226 (77 residues), 48.8 bits, E=7.1e-17
• PF08544: GHMP_kinases_C
  • amino acids 376 to 439 (64 residues), 34.5 bits, E=2.2e-12

Predicted SEED Role

"Phosphomevalonate kinase (EC 2.7.4.2)" in subsystem Archaeal lipids or Isoprenoid Biosynthesis (EC 2.7.4.2)

MetaCyc Pathways

• superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (10/10 steps found)
• mevalonate pathway I (eukaryotes and bacteria) (7/7 steps found)
• isoprene biosynthesis II (engineered) (7/8 steps found)
• superpathway of ergosterol biosynthesis I (16/26 steps found)
• superpathway of cholesterol biosynthesis (14/38 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (26/57 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.2

Protein Sequence (501 amino acids)

>mRNA_334 K00938 E2.7.4.2, mvaK2 phosphomevalonate kinase (Rhodosporidium toruloides IFO0880)
MPTIVSCPGKVLVAGGYLVLDRQHQGFVSATPSRFYTVVQDAGDAGAGVERFAVTVVSPQ
FDDGRWEYEARREDGEWVVAAVEREGSSSNTFVHLSVQAALQVASALNPSATFAPLEVTI
VGSNDFYSQSRSDSAPVPFAPLNCTIRNVHKTGLGSSAAMVTSLTSSLLLHWTSSSSSNP
SSPAGRLPNPDNDTIHLLHNLAQYVHSLAQGKVGSGFDVSAAVYGSQTYRRFAVECLGGL
LDPQANGGSKISSKDLLSVLSPSLNSAWTSPSTAGSVTSFSLPPHTLLLLADVDAGSNTP
SMVGEVMQWKKAAPEEAERVWSELGRSNEKLRDVFAELSEAAKEDAGANEREVAKLAGLT
AKEWSSSAVPFAAAAQRILDTRALMRYMGEQSGVPTEPPEQTKLLDACSALPGVIGAGVP
GAGGYDAIWVLCLDPSSASASTSPASAVESLLLSYTDMSVRPLSKNAWVRGGTFEGEAGL
LRERVEEVEGLQEAIERGKKR