Protein Info for mRNA_607 in Rhodosporidium toruloides IFO0880

Name: 8975
Annotation: K00140 mmsA, iolA, ALDH6A1 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01722: methylmalonate-semialdehyde dehydrogenase (acylating)
  • amino acids 54 to 527 (474 residues), 676.7 bits, E=8.5e-208
• PF00171: Aldedh
  • amino acids 63 to 523 (461 residues), 444.2 bits, E=4.7e-137
• PF05893: LuxC
  • amino acids 171 to 237 (67 residues), 21.5 bits, E=1.1e-08

Best Hits

Swiss-Prot: 57% identical to MMSA_AEDAE: Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (AAEL001134) from Aedes aegypti

KEGG orthology group: K00140, methylmalonate-semialdehyde dehydrogenase [EC: 1.2.1.27] (inferred from 61% identity to lbc:LACBIDRAFT_301007)

MetaCyc: 52% identical to malonate semialdehyde dehydrogenase (CoA-acylating) (Candida albicans SC5314)
Malonate-semialdehyde dehydrogenase (acetylating). [EC: 1.2.1.18]

Predicted SEED Role

"Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)" in subsystem Isobutyryl-CoA to Propionyl-CoA Module or Valine degradation (EC 1.2.1.27)

MetaCyc Pathways

• β-alanine degradation I (2/2 steps found)
• L-valine degradation I (6/8 steps found)
• β-alanine degradation II (1/2 steps found)
• propanoyl-CoA degradation II (3/5 steps found)
• 2,4-dinitrotoluene degradation (1/7 steps found)
• myo-inositol degradation I (1/7 steps found)
• myo-, chiro- and scyllo-inositol degradation (1/10 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Inositol phosphate metabolism
• Propanoate metabolism
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.18 or 1.2.1.27

Protein Sequence (545 amino acids)

>mRNA_607 K00140 mmsA, iolA, ALDH6A1 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase (Rhodosporidium toruloides IFO0880)
MLSHTLRTSGSLRTLATRRTFTTTPARRALADLEALAATHPWSGTATDGQRATTHLIGGE
YTTGDSTHWIDVHDPSTQRVLTRVPESTPQVLKRAVDKAEEAFDEWKDSSILKRQAVMLK
FQSLIREHHDEIARSIVLEQGKTFADAKGDVLRGLQVVENACGIPSLLLADKLEVSKDMD
TFVRKVPLGVTAAVCPFNFPAMIPLWAMGMSIACGNSLILKPSERDPGATMILAELLEQA
GLPKGVLQVVHGTIAPVKFICEEPRIKAISFVGGDKAGQYIYETGSKNGKRVQANLGAKN
HCILMPDANANFALNSIVGAAFGAAGQRCMALSTLVAVGESQTWIDGLVERAKKLKVGNG
FDPETEVGPLITPAAKERVESLIQSCADQGGKILLDGRGAKPKGYEKGNFVGPTILEATT
DMDCYTQEIFGPVLTIVKADTLDDAIALINRNRYGNGSSVFTNSGATARRFEKEIQAGQV
GINVPIPVPLPMFSWSGNKGSVLGGASLYGPRGVDFWTQNKTVTSYWRAEDAIDTRATTA
MPTHH