Protein Info for mRNA_899 in Rhodosporidium toruloides IFO0880

Name: 9267
Annotation: K00486 KMO kynurenine 3-monooxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01494: FAD_binding_3
  • amino acids 7 to 200 (194 residues), 40.4 bits, E=3.4e-14
  • amino acids 331 to 366 (36 residues), 33.7 bits, 3.7e-12
• PF13450: NAD_binding_8
  • amino acids 10 to 40 (31 residues), 22.2 bits, see alignment (E = 2.1e-08)

Predicted SEED Role

"Kynurenine 3-monooxygenase (EC 1.14.13.9)" in subsystem NAD and NADP cofactor biosynthesis global (EC 1.14.13.9)

MetaCyc Pathways

• NAD de novo biosynthesis II (from tryptophan) (7/9 steps found)
• superpathway of NAD biosynthesis in eukaryotes (10/14 steps found)
• L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde (3/5 steps found)
• 3-hydroxy-4-methyl-anthranilate biosynthesis II (1/5 steps found)
• 3-hydroxy-4-methyl-anthranilate biosynthesis I (1/6 steps found)
• L-tryptophan degradation III (eukaryotic) (6/15 steps found)
• L-tryptophan degradation IX (3/12 steps found)
• L-tryptophan degradation XI (mammalian, via kynurenine) (9/23 steps found)

KEGG Metabolic Maps

• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.13.9

Protein Sequence (540 amino acids)

>mRNA_899 K00486 KMO kynurenine 3-monooxygenase (Rhodosporidium toruloides IFO0880)
MSSDERTALVVGAGLVGTLTAAMLASRGWTVTLLESRSDPREGTHAERARSINLALSPRG
IEALRSVSEELAGRVVSEGIEMRGRMVHKNKVVRAKGKGREVRVEKEGQDYGRYEEEGEC
IRSISRTALGIHLLDHVDGLPSEGRGSVTTRFETKLVEMDLRKEDGVDVVLQKKGEQPEK
KHFHFVVGGDGAYSKVRQQMMRGSKLRFDYRQFYAPHSYLELSIPPGPNDTFLLEPDYLH
IWPRGEFMLIALANQDKSFTLTLFAHDSTFTSLDANLASLAPGAPNPVVELFRREFPDAL
EQMSEEALLQSWRENPKDGLITVECSPYHYKDKVLLIGDAAHAMVPFYGQGMNCGFEDVR
VLSSILDHFGASPSPLVPSPLPYSLETASLASFSKLPTEDNETPLARALSIYTHLRAPSL
AAIQTLAHQNYTEMASSVLSPLYLLRRSLDSILTSVSNVPLFAIKRDPDPLKDQGGRWES
LYRMVTFRPGLAYEEVIRRRDWQGKVLDWAAKVVGRVVVAGAVAGVGLRYAGKYRLVRVD