Protein Info for mRNA_1147 in Rhodosporidium toruloides IFO0880

Name: 9515
Annotation: KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02826: 2-Hacid_dh_C
  • amino acids 134 to 343 (210 residues), 115.7 bits, E=1.6e-37
• PF03446: NAD_binding_2
  • amino acids 173 to 296 (124 residues), 21.2 bits, E=2.8e-08

Predicted SEED Role

"D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 1.1.1.95)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (7/9 steps found)
• superpathway of L-serine and glycine biosynthesis I (3/4 steps found)
• L-cysteine biosynthesis IX (Trichomonas vaginalis) (2/3 steps found)
• L-serine biosynthesis I (2/3 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.95

Use Curated BLAST to search for 1.1.1.95

Protein Sequence (384 amino acids)

>mRNA_1147 KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) (Rhodosporidium toruloides IFO0880)
MAATTHNDAFPAMETVLVLHSLAPLSLLDDLRSTFRTVKYHPIQTRDGSISPTQPTAEDY
ATADAIFAFAVPDELQSPAQTPRLKLFQVCSSGYSQVEQHSFYKAAKEAGGAGIAWTNCA
GIQTTTIAEHVIGTVIMLLHKIHFLYWAQRAEQRWVSPREIGGFNIQDVGSLKVGVIGYG
HIGREVARLFHAFGSTVYALTRDGAPTPEKGYTLPGTGDPSGSLPTKYYATSPYSSILSF
FSACDVVVNVLPDTPRTHRTISTDEFKAMKGNAIYVNIGRGRTTDQEVLVEALRAKKEEG
EAEDATGTLRIGAASLDVTDPEPLPSSHPLYTLPTVILTPHVSGLSKDYWRRALNVLKLN
AEKLGRGVEAVNVWSGAQEGVMGQ