Protein Info for mRNA_1406 in Rhodosporidium toruloides IFO0880

Name: 9774
Annotation: K00002 AKR1A1, adh alcohol dehydrogenase (NADP+)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00248: Aldo_ket_red
  • amino acids 20 to 218 (199 residues), 123 bits, E=7.4e-40

Best Hits

Swiss-Prot: 66% identical to ALDX_SPOSA: Aldehyde reductase 1 (ARI) from Sporidiobolus salmonicolor

KEGG orthology group: None (inferred from 56% identity to pno:SNOG_02188)

MetaCyc: 54% identical to D-glyceraldehyde reductase / L-glyceraldehyde reductase (Trichoderma reesei)
Glycerol dehydrogenase (NADP(+)). [EC: 1.1.1.372, 1.1.1.72]; 1.1.1.372 [EC: 1.1.1.372, 1.1.1.72]

Predicted SEED Role

"oxidoreductase of aldo/keto reductase family, subgroup 1"

MetaCyc Pathways

• D-galacturonate degradation III (3/5 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (6/31 steps found)

KEGG Metabolic Maps

• Glycerolipid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.372 or 1.1.1.72

Protein Sequence (326 amino acids)

>mRNA_1406 K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) (Rhodosporidium toruloides IFO0880)
MSSQSVPTVQLHNGKSFPLLGFGTWQSAPGEVGNAVSVALKAGYRHLDLAKVYQNQKEIA
PAIANSGVLREEMFITSKLWNSQHRPDLVEPALDDTLKELGLSYLDLYLIHWPVAFPAEG
DPHQNLFPKANDNEVKIDDSVSLVDTWKAMIKLLDTGKVRSIGVSNFSPEMVDAITEATG
VKPVVNQIERHPHLLQRELIEHHKKANIVITAYSGFGNNSEGVPLLFQHPIVKKIAENHG
ADGGQVLIAWGMHGGHAIIPKSVTESRIQSNFKIIQLDEASIKEIDSIGEKEPRRFNLPR
AYAPSWPIDVFGEAKEQGAKYQVKIK