MetaCyc Pathway: reductive acetyl coenzyme A pathway I (homoacetogenic bacteria) in Rhodosporidium toruloides IFO0880

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Carbon-monoxide dehydrogenase (ferredoxin) (in reverse):
CO2 + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→carbon monoxide + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.2.7.4; 2.3.3.M4; 2.3.3.M5)
No genes
CO2 + NADPH→formate + NADP+ (EC 1.17.1.10)
No genes
Formate--tetrahydrofolate ligase:
formate + ATP + a tetrahydrofolate→an N10-formyltetrahydrofolate + ADP + phosphate (EC 6.3.4.3)
mRNA_6998 (15366)
Methenyltetrahydrofolate cyclohydrolase (in reverse):
an N10-formyltetrahydrofolate + H+→a 5,10-methenyltetrahydrofolate + H2O (EC 3.5.4.9)
mRNA_4257 (12625)
mRNA_6998 (15366)
Methylenetetrahydrofolate dehydrogenase (NADP(+)) (in reverse):
a 5,10-methenyltetrahydrofolate + NADPH→a 5,10-methylenetetrahydrofolate + NADP+ (EC 1.5.1.5)
mRNA_4257 (12625)
mRNA_6998 (15366)
a 5,10-methylenetetrahydrofolate + 2 NADH + 2 an oxidized ferredoxin [iron-sulfur] cluster→a 5-methyltetrahydrofolate + 2 NAD+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.5.1.M4)
No genes
a 5,10-methylenetetrahydrofolate + NADH + H+→a 5-methyltetrahydrofolate + NAD+ (EC 1.5.1.54)
No genes
Methylenetetrahydrofolate reductase (ferredoxin) (in reverse):
a 5,10-methylenetetrahydrofolate + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→a 5-methyltetrahydrofolate + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.5.7.1)
No genes
a 5-methyltetrahydrofolate + a [Co(I) corrinoid Fe-S protein] + H+→a [methyl-Co(III) corrinoid Fe-S protein] + a tetrahydrofolate (EC 2.1.1.258)
No genes
CO-methylating acetyl-CoA synthase (in reverse):
carbon monoxide + a [methyl-Co(III) corrinoid Fe-S protein] + coenzyme A→acetyl-CoA + a [Co(I) corrinoid Fe-S protein] + H+ (EC 2.3.1.169; 2.3.3.M4; 2.3.3.M5)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information