GTP cyclohydrolase I:
GTP + H2O→7,8-dihydroneopterin 3'-triphosphate + formate + H+ (EC 3.5.4.16) |
| mRNA_1964 (10332) |
Methenyltetrahydrofolate cyclohydrolase:
a 5,10-methenyltetrahydrofolate + H2O→an N10-formyltetrahydrofolate + H+ (EC 3.5.4.9) |
| mRNA_4257 (12625) |
| mRNA_6998 (15366) |
Aminodeoxychorismate synthase:
chorismate + L-glutamine→4-amino-4-deoxychorismate + L-glutamate (EC 2.6.1.85) |
| mRNA_5301 (13669) |
Aminodeoxychorismate lyase:
4-amino-4-deoxychorismate→4-aminobenzoate + H+ + pyruvate (EC 4.1.3.38) |
| No genes |
Phosphoribosylglycinamide formyltransferase:
an N10-formyltetrahydrofolate + N1-(5-phospho-β-D-ribosyl)glycinamide→a tetrahydrofolate + N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + H+ (EC 2.1.2.2) |
| mRNA_5227 (13595) |
| 7,8-dihydroneopterin 3'-triphosphate + H2O→7,8-dihydroneopterin 3'-phosphate + diphosphate + H+ (EC 3.6.1.67) |
| mRNA_7017 (15385) |
| 7,8-dihydroneopterin 3'-phosphate + H2O→D-erythro-7,8-dihydroneopterin + phosphate |
| No genes |
Dihydroneopterin aldolase:
D-erythro-7,8-dihydroneopterin→6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde (EC 4.1.2.25) |
| No genes |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase:
6-(hydroxymethyl)-7,8-dihydropterin + ATP→(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+ (EC 2.7.6.3) |
| mRNA_6009 (14377) |
Dihydropteroate synthase:
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate→7,8-dihydropteroate + diphosphate (EC 2.5.1.15) |
| mRNA_6009 (14377) |
Dihydrofolate synthase:
7,8-dihydropteroate + ATP + L-glutamate→7,8-dihydrofolate monoglutamate + ADP + H+ + phosphate (EC 6.3.2.12) |
| mRNA_2092 (10460) |
| mRNA_6435 (14803) |
Dihydrofolate reductase (in reverse):
a 7,8-dihydrofolate + NADPH + H+→a tetrahydrofolate + NADP+ (EC 1.5.1.3) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information