MetaCyc Pathway: L-lysine biosynthesis IV in Rhodosporidium toruloides IFO0880

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Homocitrate synthase:
2-oxoglutarate + acetyl-CoA + H2O→(2R)-homocitrate + coenzyme A + H+ (EC 2.3.3.14)
mRNA_6488 (14856)
Methanogen homoaconitase:
(2R)-homocitrate→cis-homoaconitate + H2O (spontaneous) (EC 4.2.1.114)
No genes
Methanogen homoaconitase (in reverse):
cis-homoaconitate + H2O→(1R,2S)-homoisocitrate (EC 4.2.1.114; 4.2.1.36)
mRNA_7648 (16016)
Isocitrate--homoisocitrate dehydrogenase:
(1R,2S)-homoisocitrate + NAD+→2-oxoadipate + CO2 + NADH (EC 1.1.1.286; 1.1.1.87)
mRNA_2060 (10428)
2-aminoadipate transaminase (in reverse):
2-oxoadipate + L-glutamate→2-oxoglutarate + L-2-aminoadipate (EC 2.6.1.39)
No genes
L-2-aminoadipate[cytosol] + ATP[cytosol] + a holo-[LYS2 L-2-aminoadipyl-carrier-protein][cytosol]→an L-2-aminoadipyl-[LYS2 L-2-aminoadipyl-carrier-protein][cytosol] + AMP[cytosol] + diphosphate[cytosol] (EC 1.2.1.95)
No genes
an L-2-aminoadipyl-[LYS2 L-2-aminoadipyl-carrier-protein] + NADPH + H+→(S)-2-amino-6-oxohexanoate + a holo-[LYS2 L-2-aminoadipyl-carrier-protein] + NADP+ (EC 1.2.1.95)
No genes
Saccharopine dehydrogenase (NADP(+), L-glutamate-forming) (in reverse):
(S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H+→L-saccharopine + NADP+ + H2O (EC 1.5.1.10)
No genes
Saccharopine dehydrogenase (NAD(+), L-lysine-forming):
L-saccharopine + NAD+ + H2O→2-oxoglutarate + L-lysine + NADH + H+ (EC 1.5.1.7)
mRNA_5719 (14087)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information