Nicotine dehydrogenase:
(S)-nicotine + an oxidized pseudoazurin + H2O→(S)-6-hydroxynicotine + 2 H+ + a reduced pseudoazurin (EC 1.5.99.4) |
| No genes |
Nicotine dehydrogenase:
(R)-nicotine + an oxidized unknown electron carrier + H2O→(R)-6-hydroxynicotine + a reduced unknown two electron carrier (EC 1.5.99.4) |
| No genes |
(S)-6-hydroxynicotine oxidase:
(S)-6-hydroxynicotine + dioxygen→6-hydroxy-N-methylmyosmine + hydrogen peroxide (EC 1.5.3.5) |
| No genes |
(R)-6-hydroxynicotine oxidase:
(R)-6-hydroxynicotine + dioxygen→6-hydroxy-N-methylmyosmine + hydrogen peroxide (EC 1.5.3.6) |
| No genes |
(S)-6-hydroxynicotine oxidase:
6-hydroxy-N-methylmyosmine + H2O→6-hydroxypseudooxynicotine (spontaneous) (EC 1.5.3.5; 1.5.3.6) |
| No genes |
| 6-hydroxypseudooxynicotine + an oxidized unknown electron carrier + H2O→2,6-dihydroxypseudooxynicotine + a reduced unknown two electron carrier (EC 1.5.99.14) |
| No genes |
| 2,6-dihydroxypseudooxynicotine + H2O→2,6-dihydroxypyridine + 4-methylaminobutanoate + H+ (EC 3.7.1.19) |
| No genes |
2,6-dihydroxypyridine 3-monooxygenase:
2,6-dihydroxypyridine + NADH + dioxygen + H+→2,3,6-trihydroxypyridine + NAD+ + H2O (EC 1.14.13.10) |
| No genes |
| 4-methylaminobutanoate + dioxygen + H2O→succinate semialdehyde + hydrogen peroxide + methylamine (EC 1.5.3.21) |
| No genes |
| 4-methylaminobutanoate + dioxygen + H2O→4-aminobutanoate + formaldehyde + hydrogen peroxide (EC 1.5.3.19) |
| No genes |
4-aminobutyrate transaminase:
4-aminobutanoate + 2-oxoglutarate→succinate semialdehyde + L-glutamate (EC 2.6.1.19) |
| mRNA_2569 (10937) |
| mRNA_7537 (15905) |
| 2,3,6-trihydroxypyridine→6,3-dihydroxy-2-pyridinone + H+ (spontaneous) |
| No genes |
| 2 6,3-dihydroxy-2-pyridinone + 2 an oxidized unknown electron carrier→nicotine blue + 2 a reduced unknown two electron carrier (spontaneous) |
| No genes |
| 6,3-dihydroxy-2-pyridinone + H2O→2-oxoglutaramate |
| No genes |
| succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79) |
| No genes |
| nicotine blue + NAD(P)H + 3 H+→nicotine blue leuco form + NAD(P)+ (EC 1.1.1.328) |
| No genes |
| 2-oxoglutaramate + H2O→2-oxoglutarate + ammonium (EC 3.5.1.111; 3.5.1.3) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information