MetaCyc Pathway: coenzyme B biosynthesis in Rhodosporidium toruloides IFO0880

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Homocitrate synthase:
2-oxoglutarate + acetyl-CoA + H2O→(2R)-homocitrate + coenzyme A + H+ (EC 2.3.3.14)
mRNA_6488 (14856)
Methanogen homoaconitase:
(2R)-homocitrate→cis-homoaconitate + H2O (spontaneous) (EC 4.2.1.114)
No genes
Methanogen homoaconitase (in reverse):
cis-homoaconitate + H2O→(1R,2S)-homoisocitrate (EC 4.2.1.114; 4.2.1.36)
mRNA_7648 (16016)
Isocitrate--homoisocitrate dehydrogenase:
(1R,2S)-homoisocitrate + NAD+→2-oxoadipate + CO2 + NADH (EC 1.1.1.286; 1.1.1.87)
mRNA_2060 (10428)
2-oxoadipate + acetyl-CoA + H2O→dihomocitrate + coenzyme A + H+
No genes
Methanogen homoaconitase:
dihomocitrate→cis-(homo)2aconitate + H2O (EC 4.2.1.114)
No genes
Methanogen homoaconitase:
cis-(homo)2aconitate + H2O→(-)threo-iso(homo)2citrate (EC 4.2.1.114)
No genes
(-)threo-iso(homo)2citrate + NAD+→2-oxopimelate + CO2 + NADH
No genes
2-oxopimelate + acetyl-CoA + H2O→trihomocitrate + coenzyme A + H+
No genes
Methanogen homoaconitase:
trihomocitrate→cis-(homo)3aconitate + H2O (EC 4.2.1.114)
No genes
Methanogen homoaconitase:
cis-(homo)3aconitate + H2O→(-)threo-iso(homo)3citrate (EC 4.2.1.114)
No genes
(-)threo-iso(homo)3citrate + NAD+→2-oxosuberate + CO2 + NADH
No genes
2-oxosuberate + H+→7-oxoheptanoate + CO2
No genes
7-oxoheptanoate + a reduced unknown two electron carrier + hydrogen sulfide→7-mercaptoheptanoate + an oxidized unknown electron carrier + H2O
No genes
7-mercaptoheptanoate + ATP + L-threonine→7-mercaptoheptanoylthreonine + ADP + H+ + phosphate
No genes
7-mercaptoheptanoylthreonine + ATP→coenzyme B + ADP + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information