MetaCyc Pathway: superpathway of aromatic compound degradation via 3-oxoadipate in Rhodosporidium toruloides IFO0880

Add experiment(s):


L-quinate + a quinone→3-dehydroquinate + a quinol (EC 1.1.5.8)
No genes
Mandelate racemase (in reverse):
(R)-4-hydroxymandelate→(S)-4-hydroxymandelate
(EC 5.1.2.2)
No genes
Mandelate racemase (in reverse):
(R)-mandelate→(S)-mandelate
(EC 5.1.2.2)
No genes
Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygenN-Formyl-L-kynurenine
(EC 1.13.11.11; 1.13.11.52)
No genes
shikimate + a quinone→3-dehydroshikimate + a quinol (EC 1.1.5.8)
No genes
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O
(EC 4.2.1.10)
mRNA_2204 (10572)
mRNA_4451 (12819)
mRNA_5884 (14252)
mRNA_8034 (16402)
mRNA_669 (9037)
(S)-4-hydroxymandelate + an electron-transfer quinone→4-hydroxyphenylglyoxylate + an electron-transfer quinol
No genes
Arylformamidase:
N-Formyl-L-kynurenine + H2O→L-kynurenine + formate + H+
(EC 3.5.1.9)
No genes
(S)-mandelate dehydrogenase:
(S)-mandelate + an oxidized unknown electron carrier→phenylglyoxylate + a reduced unknown two electron carrier
(EC 1.1.99.31)
No genes
Benzoylformate decarboxylase:
phenylglyoxylate + H+→benzaldehyde + CO2
(EC 4.1.1.7)
No genes
3-dehydroshikimate→protocatechuate + H2O (EC 4.2.1.118)
mRNA_3472 (11840)
mRNA_738 (9106)
Benzoylformate decarboxylase:
4-hydroxyphenylglyoxylate + H+→4-hydroxybenzaldehyde + CO2
(EC 4.1.1.7)
No genes
Kynureninase:
L-kynurenine + H2O→anthranilate + L-alanine + H+
(EC 3.7.1.3)
mRNA_357 (8725)
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating):
anthranilate + NAD(P)H + dioxygen + 3 H+→catechol + ammonium + CO2 + NAD(P)+
(EC 1.14.12.1)
No genes
Benzaldehyde dehydrogenase (NAD(+)):
benzaldehyde + NAD+ + H2O→benzoate + NADH + 2 H+
(EC 1.2.1.28)
No genes
Benzaldehyde dehydrogenase (NADP(+)):
benzaldehyde + NADP+ + H2O→benzoate + NADPH + 2 H+
(EC 1.2.1.7)
No genes
4-hydroxybenzaldehyde dehydrogenase:
4-hydroxybenzaldehyde + NAD+ + H2O→4-hydroxybenzoate + NADH + 2 H+
(EC 1.2.1.64)
No genes
4-hydroxybenzaldehyde + NADP+ + H2O→4-hydroxybenzoate + NADPH + 2 H+ (EC 1.2.1.96)
No genes
4-hydroxybenzoate 3-monooxygenase:
4-hydroxybenzoate + NADPH + dioxygen + H+→protocatechuate + NADP+ + H2O
(EC 1.14.13.2)
No genes
Benzoate 1,2-dioxygenase:
benzoate + NADH + dioxygen + H+→3,5-cyclohexadiene-1,2-diol-1-carboxylate + NAD+
(EC 1.14.12.10)
No genes
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase:
3,5-cyclohexadiene-1,2-diol-1-carboxylate + NAD+→catechol + CO2 + NADH
(EC 1.3.1.25)
No genes
Protocatechuate 3,4-dioxygenase:
protocatechuate + dioxygen→3-carboxy-cis,cis-muconate + 2 H+
(EC 1.13.11.3)
No genes
3-carboxy-cis,cis-muconate cycloisomerase (in reverse):
3-carboxy-cis,cis-muconate + H+→(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate
(EC 5.5.1.2)
No genes
Catechol 1,2-dioxygenase:
catechol + dioxygen→cis,cis-muconate + 2 H+
(EC 1.13.11.1)
mRNA_3938 (12306)
mRNA_267 (8635)
mRNA_732 (9100)
Catechol 2,3-dioxygenase:
catechol + dioxygen→(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H+
(EC 1.13.11.2)
No genes
2-hydroxymuconate-semialdehyde hydrolase:
(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O→(2Z)-2-hydroxypenta-2,4-dienoate + formate + H+
(EC 3.7.1.9)
No genes
4-carboxymuconolactone decarboxylase:
(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate + H+→(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2
(EC 4.1.1.44)
No genes
Muconate cycloisomerase (in reverse):
cis,cis-muconate + H+→(+)-muconolactone
(EC 5.5.1.1)
No genes
2-oxopent-4-enoate hydratase (in reverse):
(2Z)-2-hydroxypenta-2,4-dienoate + H2O→(S)-4-hydroxy-2-oxopentanoate
(EC 4.2.1.80)
No genes
Muconolactone Delta-isomerase:
(+)-muconolactone→(4,5-dihydro-5-oxofuran-2-yl)-acetate
(EC 5.3.3.4)
No genes
3-oxoadipate enol-lactonase:
(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O→3-oxoadipate + H+
(EC 3.1.1.24)
No genes
4-hydroxy-2-oxovalerate aldolase:
(S)-4-hydroxy-2-oxopentanoate→acetaldehyde + pyruvate
(EC 4.1.3.39)
No genes
3-oxoadipate CoA-transferase:
3-oxoadipate + succinyl-CoA→3-oxoadipyl-CoA + succinate
(EC 2.8.3.6)
No genes
Acetaldehyde dehydrogenase (acetylating):
acetaldehyde + coenzyme A + NAD+→acetyl-CoA + NADH + H+
(EC 1.2.1.10)
No genes
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipyl-CoA + coenzyme A→acetyl-CoA + succinyl-CoA
(EC 2.3.1.174)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information