MetaCyc Pathway: L-lysine biosynthesis V in Rhodosporidium toruloides IFO0880

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Homocitrate synthase:
2-oxoglutarate + acetyl-CoA + H2O→(2R)-homocitrate + coenzyme A + H+ (EC 2.3.3.14)
mRNA_6488 (14856)
Methanogen homoaconitase:
(2R)-homocitrate→cis-homoaconitate + H2O (spontaneous) (EC 4.2.1.114)
No genes
Methanogen homoaconitase (in reverse):
cis-homoaconitate + H2O→(1R,2S)-homoisocitrate (EC 4.2.1.114; 4.2.1.36)
mRNA_7648 (16016)
Isocitrate--homoisocitrate dehydrogenase:
(1R,2S)-homoisocitrate + NAD+→2-oxoadipate + CO2 + NADH (EC 1.1.1.286; 1.1.1.87)
mRNA_2060 (10428)
2-aminoadipate transaminase (in reverse):
2-oxoadipate + L-glutamate→2-oxoglutarate + L-2-aminoadipate (EC 2.6.1.39)
No genes
L-2-aminoadipate + ATP + an [amino-group carrier protein]-C-terminal-L-glutamate→an [amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] + ADP + H+ + phosphate (EC 6.3.2.43)
No genes
an [amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] + ATP→an [amino-group carrier protein]-C-terminal-{N-[1-carboxy-5-oxo-5-(phosphooxy)pentyl]-L-glutamine} + ADP (EC 2.7.2.17)
No genes
an [amino-group carrier protein]-C-terminal-{N-[1-carboxy-5-oxo-5-(phosphooxy)pentyl]-L-glutamine} + NADPH + H+→an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine] + NADP+ + phosphate (EC 1.2.1.103)
No genes
an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine] + L-glutamate→2-oxoglutarate + an [amino-group carrier protein]-C-terminal-[γ-(L-lysyl)-L-glutamate] (EC 2.6.1.118)
No genes
an [amino-group carrier protein]-C-terminal-[γ-(L-lysyl)-L-glutamate] + H2O→L-lysine + an [amino-group carrier protein]-C-terminal-L-glutamate (EC 3.5.1.130)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information