MetaCyc Pathway: arsenic detoxification (mammals) in Rhodosporidium toruloides IFO0880

Add experiment(s):


arsenate[out] + Na+[out]→arsenate[in] + Na+[in]
No genes
arsenous acid[out]→arsenous acid[in]
No genes
Purine-nucleoside phosphorylase:
arsenate + a purine ribonucleoside→ribose-1-arsenate + a purine base (EC 2.4.2.1)
mRNA_7908 (16276)
ribose-1-arsenate + dihydrolipoate + 2 H+→arsenous acid + D-ribofuranose + (R)-lipoate (spontaneous)
No genes
arsenous acid + 3 glutathione→arsenic triglutathione + 3 H2O (spontaneous)
No genes
Arsenite methyltransferase:
arsenic triglutathione + an [arsenite methyltransferase]→an arsenite-[arsenite methyltransferase] + 3 glutathione (EC 2.1.1.137)
No genes
Arsenite methyltransferase:
an arsenite-[arsenite methyltransferase] + a reduced thioredoxin + S-adenosyl-L-methionine→a methylarsenite-[arsenite methyltransferase] + S-adenosyl-L-homocysteine + an oxidized thioredoxin + H+ (EC 2.1.1.137)
No genes
Arsenite methyltransferase:
a methylarsenite-[arsenite methyltransferase] + 2 H2O→methylarsonous acid + an [arsenite methyltransferase] (EC 2.1.1.137)
No genes
Arsenite methyltransferase:
a methylarsenite-[arsenite methyltransferase] + a reduced thioredoxin + S-adenosyl-L-methionine→a dimethylarsenite-[arsenite methyltransferase] + S-adenosyl-L-homocysteine + an oxidized thioredoxin + H+ (EC 2.1.1.137)
No genes
methylarsonous acid + 2 glutathione→monomethylarsino-diglutathione + 2 H2O (spontaneous)
No genes
Arsenite methyltransferase:
a dimethylarsenite-[arsenite methyltransferase] + H2O→dimethylarsinous acid + an [arsenite methyltransferase] (EC 2.1.1.137)
No genes
Arsenite methyltransferase:
a dimethylarsenite-[arsenite methyltransferase] + a reduced thioredoxin + S-adenosyl-L-methionine→trimethylarsane + S-adenosyl-L-homocysteine + an [arsenite methyltransferase] + an oxidized thioredoxin + H+ (EC 2.1.1.137)
No genes
2 methylarsonous acid + dioxygen→2 methylarsonate + 2 H+ (spontaneous)
No genes
Methylarsonate reductase:
methylarsonate + 2 glutathione + H+→methylarsonous acid + glutathione disulfide + H2O (EC 1.20.4.2)
No genes
2 dimethylarsinous acid + dioxygen→2 cacodylate + 2 H+ (spontaneous)
No genes
monomethylarsino-diglutathione + a reduced thioredoxin + S-adenosyl-L-methionine + H2O→dimethylarsinous acid + S-adenosyl-L-homocysteine + 2 glutathione + an oxidized thioredoxin + H+
mRNA_4594 (12962)
dimethylarsinous acid + glutathione→dimethylarsino-glutathione + H2O (spontaneous)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information