MetaCyc Pathway: superpathway of L-citrulline metabolism in Rhodosporidium toruloides IFO0880

Add experiment(s):


Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonium (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 3.5.1.2; 3.5.1.38; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
mRNA_1908 (10276)
mRNA_3000 (11368)
mRNA_3068 (11436)
mRNA_3934 (12302)
mRNA_4272 (12640)
mRNA_4929 (13297)
mRNA_6769 (15137)
mRNA_7345 (15713)
mRNA_7388 (15756)
mRNA_8107 (16475)
mRNA_8247 (16615)
mRNA_8313 (16681)
Carbamoyl-phosphate synthase (ammonia):
ammonium + 2 ATP + hydrogencarbonate→carbamoyl phosphate + 2 ADP + 2 H+ + phosphate (EC 6.3.4.16; 6.3.5.5)
mRNA_3934 (12302)
mRNA_4929 (13297)
mRNA_8313 (16681)
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
No genes
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
mRNA_6820 (15188)
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate-5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate-5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
mRNA_7905 (16273)
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate-5-semialdehyde→L-ornithine + 2-oxoglutarate (EC 2.6.1.13)
mRNA_6698 (15066)
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate (EC 2.1.3.3)
mRNA_4934 (13302)
Argininosuccinate synthase:
L-citrulline + ATP + L-aspartate→L-arginino-succinate + AMP + diphosphate + H+ (EC 6.3.4.5)
mRNA_7828 (16196)
Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)
mRNA_3236 (11604)
Arginase:
L-arginine + H2O→L-ornithine + urea (EC 3.5.3.1)
mRNA_7813 (16181)
Nitric-oxide synthase:
2 L-arginine + 3 NADPH + 4 dioxygen + H+→2 L-citrulline + 3 NADP+ + 2 nitric oxide + 4 H2O (EC 1.14.13.39)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information