MetaCyc Pathway: secologanin and strictosidine biosynthesis in Rhodosporidium toruloides IFO0880

Add experiment(s):


L-tryptophan + H+→tryptamine + CO2 (EC 4.1.1.105; 4.1.1.28)
mRNA_1736 (10104)
mRNA_5309 (13677)
geranyl diphosphate + H2O→geraniol + diphosphate (EC 3.1.7.11)
No genes
geraniol + dioxygen + a reduced [NADPH-hemoprotein reductase]→(6E)-8-hydroxygeraniol + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.83)
No genes
(6E)-8-hydroxygeraniol + NADP+→(6E)-8-hydroxygeranial + NADPH + H+ (EC 1.1.1.324)
No genes
(6E)-8-hydroxygeraniol + NADP+→(6E)-8-oxogeraniol + NADPH + H+ (EC 1.1.1.324)
No genes
(6E)-8-hydroxygeranial + NADP+→(6E)-8-oxogeranial + NADPH + H+ (EC 1.1.1.324)
No genes
(6E)-8-oxogeraniol + NADP+→(6E)-8-oxogeranial + NADPH + H+ (EC 1.1.1.324)
No genes
(6E)-8-oxogeranial + NAD(P)H + H+→(S)-8-oxocitronellyl enol + NAD(P)+ (EC 1.3.1.122)
No genes
(S)-8-oxocitronellyl enol→(+)-cis,trans-nepetalactol (EC 5.5.1.34)
No genes
(+)-cis,trans-nepetalactol + dioxygen + a reduced [NADPH-hemoprotein reductase]→7-deoxyloganetic alcohol + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.161)
No genes
7-deoxyloganetic alcohol + dioxygen + a reduced [NADPH-hemoprotein reductase]→iridotrial + an oxidized [NADPH-hemoprotein reductase] + 2 H2O (EC 1.14.14.161)
No genes
iridotrial + dioxygen + a reduced [NADPH-hemoprotein reductase]→7-deoxyloganetate + an oxidized [NADPH-hemoprotein reductase] + H+ + H2O (EC 1.14.14.161)
No genes
7-deoxyloganetate + UDP-α-D-glucose→7-deoxyloganate + H+ + UDP (EC 2.4.1.323)
No genes
7-deoxyloganate + dioxygen + a reduced [NADPH-hemoprotein reductase]→loganate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.85)
No genes
Loganate O-methyltransferase:
loganate + S-adenosyl-L-methionine→loganin + S-adenosyl-L-homocysteine (EC 2.1.1.50)
No genes
loganin + dioxygen + a reduced [NADPH-hemoprotein reductase]→secologanin + an oxidized [NADPH-hemoprotein reductase] + 2 H2O (EC 1.14.19.62)
No genes
Strictosidine synthase:
secologanin + tryptamine→3-α(S)-strictosidine + H2O (EC 4.3.3.2)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information