MetaCyc Pathway: superpathway of L-lysine degradation in Rhodosporidium toruloides IFO0880

Add experiment(s):


Saccharopine dehydrogenase (NADP(+), L-lysine-forming) (in reverse):
L-lysine + 2-oxoglutarate + NADPH + H+→L-saccharopine + NADP+ + H2O (EC 1.5.1.8)
mRNA_2209 (10577)
L-lysine 6-transaminase:
L-lysine + 2-oxoglutarate→(S)-2-amino-6-oxohexanoate + L-glutamate (EC 2.6.1.36)
No genes
L-lysine oxidase:
L-lysine + dioxygen + H2O→6-amino-2-oxohexanoate + ammonium + hydrogen peroxide (EC 1.4.3.14)
No genes
L-lysine + acetyl-CoA→N6-acetyl-L-lysine + coenzyme A + H+ (EC 2.3.1.dw)
No genes
Lysine decarboxylase:
L-lysine + H+→cadaverine + CO2 (EC 4.1.1.18)
No genes
Lysine--pyruvate 6-transaminase:
L-lysine + pyruvate→(S)-2-amino-6-oxohexanoate + L-alanine (EC 2.6.1.71)
No genes
Lysine 2-monooxygenase:
L-lysine + dioxygen→5-aminopentanamide + CO2 + H2O (EC 1.13.12.2)
No genes
Lysine 2,3-aminomutase:
L-lysine→L-β-lysine (EC 5.4.3.2)
No genes
Lysine racemase:
L-lysine→D-lysine (EC 5.1.1.5)
No genes
Lysine 6-dehydrogenase:
L-lysine + NAD+ + H2O→(S)-2-amino-6-oxohexanoate + ammonium + NADH + H+ (EC 1.4.1.18)
No genes
Saccharopine dehydrogenase (NAD(+), L-glutamate-forming):
L-saccharopine + NAD+ + H2O→(S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H+ (EC 1.5.1.9)
mRNA_2209 (10577)
5-aminopentanamidase:
5-aminopentanamide + H2O→5-aminopentanoate + ammonium (EC 3.5.1.30)
No genes
N6-acetyl-L-lysine + 2-oxoglutarate→2-keto-6-acetamidocaproate + L-glutamate
No genes
Beta-lysine 5,6-aminomutase:
L-β-lysine→(3S,5S)-3,5-diaminohexanoate (EC 5.4.3.3)
No genes
D-amino-acid oxidase:
D-lysine + dioxygen + H2O→6-amino-2-oxohexanoate + ammonium + hydrogen peroxide (EC 1.4.3.3)
mRNA_7081 (15449)
L-aminoadipate-semialdehyde dehydrogenase:
(S)-2-amino-6-oxohexanoate→1-piperideine 6-carboxylate + H+ + H2O (spontaneous) (EC 1.2.1.31; 1.4.1.18)
mRNA_7446 (15814)
mRNA_1127 (9495)
6-amino-2-oxohexanoate + hydrogen peroxide→5-aminopentanoate + CO2 + H2O (spontaneous)
No genes
Putrescine aminotransferase:
cadaverine + 2-oxoglutarate→5-aminopentanal + glutamate (EC 2.6.1.82)
No genes
L-aminoadipate-semialdehyde dehydrogenase:
(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O→L-2-aminoadipate + NAD(P)H + 2 H+ (EC 1.2.1.31)
mRNA_7446 (15814)
mRNA_1127 (9495)
L-erythro-3,5-diaminohexanoate dehydrogenase:
(3S,5S)-3,5-diaminohexanoate + NAD+ + H2O→(S)-5-amino-3-oxohexanoate + ammonium + NADH + H+ (EC 1.4.1.11)
No genes
2-keto-6-acetamidocaproate + NAD+ + H2O→5-acetamidovalerate + CO2 + NADH + H+
No genes
6-amino-2-oxohexanoate→1-piperideine-2-carboxylate + H+ + H2O (spontaneous)
No genes
Aminobutyraldehyde dehydrogenase:
5-aminopentanal + NAD+ + H2O→5-aminopentanoate + NADH + 2 H+ (EC 1.2.1.19)
mRNA_1883 (10251)
5-acetamidovalerate + H2O→5-aminopentanoate + acetate
No genes
(S)-5-amino-3-oxohexanoate + acetyl-CoA→acetoacetate + (S)-3-aminobutanoyl-CoA (EC 2.3.1.247)
No genes
Pyrroline-2-carboxylate reductase (in reverse):
1-piperideine-2-carboxylate + NAD(P)H + 2 H+→L-pipecolate + NAD(P)+ (EC 1.5.1.1)
No genes
3-aminobutyryl-CoA ammonia-lyase:
(S)-3-aminobutanoyl-CoA→crotonyl-CoA + ammonium (EC 4.3.1.14)
No genes
L-pipecolate oxidase:
L-pipecolate + dioxygen→1-piperideine 6-carboxylate + hydrogen peroxide + H+ (EC 1.5.3.7)
No genes
5-aminovalerate transaminase:
5-aminopentanoate + 2-oxoglutarate→glutarate semialdehyde + L-glutamate (EC 2.6.1.48)
No genes
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
L-aminoadipate-semialdehyde dehydrogenase:
1-piperideine 6-carboxylate + NAD+ + 2 H2O→L-2-aminoadipate + NADH + H+ (EC 1.2.1.31)
mRNA_7446 (15814)
mRNA_1127 (9495)
Glutarate-semialdehyde dehydrogenase:
glutarate semialdehyde + NADP+ + H2O→glutarate + NADPH + 2 H+ (EC 1.2.1.20)
No genes
2-aminoadipate transaminase:
L-2-aminoadipate + 2-oxoglutarate→2-oxoadipate + L-glutamate (EC 2.6.1.39)
No genes
Butyrate--acetoacetate CoA-transferase:
acetoacetate + butanoyl-CoA→acetoacetyl-CoA + butanoate (EC 2.8.3.9)
No genes
Succinate--hydroxymethylglutarate CoA-transferase:
glutarate + succinyl-CoA→glutaryl-CoA + succinate (EC 2.8.3.13)
No genes
2-oxoglutarate + glutarate + dioxygen→(S)-2-hydroxyglutarate + CO2 + succinate (EC 1.14.11.64)
No genes
2-oxoadipate + coenzyme A + NAD+→glutaryl-CoA + CO2 + NADH (EC 1.2.1.105)
No genes
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
mRNA_5445 (13813)
mRNA_5687 (14055)
mRNA_6860 (15228)
mRNA_310 (8678)
mRNA_517 (8885)
mRNA_697 (9065)
2-oxoadipate + dioxygen→(R)-2-hydroxyglutarate + CO2 (EC 1.13.11.M16)
No genes
(S)-2-hydroxyglutarate + an electron-transfer quinone→2-oxoglutarate + an electron-transfer quinol (EC 1.1.5.13)
No genes
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
No genes
(R)-2-hydroxyglutarate + an oxidized unknown electron carrier→2-oxoglutarate + a reduced unknown two electron carrier (EC 1.1.99.39)
No genes
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
mRNA_5015 (13383)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information