MetaCyc Pathway: L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde in Rhodosporidium toruloides IFO0880

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Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygen→N-Formyl-L-kynurenine (EC 1.13.11.11; 1.13.11.52)
No genes
Arylformamidase:
N-Formyl-L-kynurenine + H2O→L-kynurenine + formate + H+ (EC 3.5.1.9)
No genes
Kynurenine 3-monooxygenase:
L-kynurenine + NADPH + dioxygen + H+→3-hydroxy-L-kynurenine + NADP+ + H2O (EC 1.14.13.9)
mRNA_899 (9267)
Kynureninase:
3-hydroxy-L-kynurenine + H2O→3-hydroxyanthranilate + L-alanine + H+ (EC 3.7.1.3)
mRNA_357 (8725)
3-hydroxyanthranilate 3,4-dioxygenase:
3-hydroxyanthranilate + dioxygen→2-amino-3-carboxymuconate-6-semialdehyde (EC 1.13.11.6)
mRNA_234 (8602)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information