MetaCyc Pathway: superpathway of phylloquinol biosynthesis in Rhodosporidium toruloides IFO0880

Add experiment(s):


Farnesyltranstransferase:
(2E,6E)-farnesyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranylgeranyl diphosphate + diphosphate
(EC 2.5.1.29)
mRNA_8135 (16503)
Isochorismate synthase:
chorismate→isochorismate
(EC 5.4.4.2)
No genes
synthase:
isochorismate + 2-oxoglutarate + H+→2-succinyl-5-enolpyruvoyl-6-hydroxy-3-cyclohexene-1-carboxylate + CO2
(EC 2.2.1.9)
No genes
Geranylgeranyl diphosphate reductase (in reverse):
geranylgeranyl diphosphate + NADPH + H+→dihydrogeranylgeranyl diphosphate + NADP+
(EC 1.3.1.83)
No genes
Geranylgeranyl diphosphate reductase (in reverse):
dihydrogeranylgeranyl diphosphate + NADPH + H+→tetrahydrogeranylgeranyl diphosphate + NADP+
(EC 1.3.1.83)
No genes
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase:
2-succinyl-5-enolpyruvoyl-6-hydroxy-3-cyclohexene-1-carboxylate→(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
(EC 4.2.99.20)
No genes
o-succinylbenzoate synthase:
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate→2-succinylbenzoate + H2O
(EC 4.2.1.113)
No genes
Geranylgeranyl diphosphate reductase (in reverse):
tetrahydrogeranylgeranyl diphosphate + NADPH + H+→phytyl diphosphate + NADP+
(EC 1.3.1.83)
No genes
o-succinylbenzoate--CoA ligase:
2-succinylbenzoate + ATP + coenzyme A→4-(2'-carboxyphenyl)-4-oxobutyryl-CoA + AMP + diphosphate
(EC 6.2.1.26)
No genes
Naphthoate synthase:
4-(2'-carboxyphenyl)-4-oxobutyryl-CoA + H+→1,4-dihydroxy-2-naphthoyl-CoA + H2O
(EC 4.1.3.36)
No genes
1,4-dihydroxy-2-naphthoyl-CoA + H2O→1,4-dihydroxy-2-naphthoate + coenzyme A + H+ (EC 3.1.2.28)
No genes
1,4-dihydroxy-2-naphthoate + an oxidized unknown electron carrier→2-carboxy-1,4-naphthoquinone + a reduced unknown two electron carrier
No genes
2-carboxy-1,4-naphthoquinone + phytyl diphosphate + H+→demethylphylloquinone + CO2 + diphosphate (EC 2.5.1.130)
No genes
demethylphylloquinone + NADPH + H+→demethylphylloquinol + NADP+ (EC 1.6.5.12)
No genes
demethylphylloquinol + S-adenosyl-L-methionine→phylloquinol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.329)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information