MetaCyc Pathway: ephedrine biosynthesis in Rhodosporidium toruloides IFO0880

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Phenylalanine ammonia-lyase:
L-phenylalanine→cinnamate + ammonium
(EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
mRNA_8094 (16462)
cinnamate + NAD+ + 2 H2O→benzoate + acetate + NADH + 2 H+
No genes
benzoate + pyruvate→1-phenyl-1,2-propanedione + CO2
No genes
1-phenyl-1,2-propanedione + L-glutamate→(S)-cathinone + 2-oxoglutarate
No genes
(S)-cathinone + NADH + H+→(1R,2S)-norephedrine + NAD+
No genes
(S)-cathinone + NADH + H+→(1S,2S)-norpseudoephedrine + NAD+
No genes
(1R,2S)-norephedrine + S-adenosyl-L-methionine→(1R,2S)-ephedrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M76)
No genes
(1S,2S)-norpseudoephedrine + S-adenosyl-L-methionine→(1S,2S)-pseudoephedrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M76)
No genes
(1R,2S)-ephedrine + S-adenosyl-L-methionine→(1R,2S)-N-methylephedrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M76)
No genes
(1S,2S)-pseudoephedrine + S-adenosyl-L-methionine→(+)-(1S,2S)-N-methylpseudoephedrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M76)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information