MetaCyc Pathway: hypusine biosynthesis in Rhodosporidium toruloides IFO0880

Add experiment(s):


Homospermidine synthase:
spermidine + NAD+→(E)-(4-aminobutylidene)(3-aminopropyl)amine + NADH + H+ (EC 2.5.1.44; 2.5.1.45; 2.5.1.46)
mRNA_1830 (10198)
Deoxyhypusine synthase:
(E)-(4-aminobutylidene)(3-aminopropyl)amine + a [deoxyhypusine synthase]-L-lysine→a [deoxyhypusine synthase]-N-(4-aminobutylidene)-lysine + propane-1,3-diamine (EC 2.5.1.46)
mRNA_1830 (10198)
Deoxyhypusine synthase:
a [deoxyhypusine synthase]-N-(4-aminobutylidene)-lysine + an [eIF5A-precursor]-lysine→an [eIF5A-precursor]-N-(4-aminobutylidene)-lysine + a [deoxyhypusine synthase]-L-lysine + H+ (EC 2.5.1.46)
mRNA_1830 (10198)
Deoxyhypusine synthase:
an [eIF5A-precursor]-N-(4-aminobutylidene)-lysine + NADH + H+→an [eIF5A-precursor]-deoxyhypusine + NAD+ (EC 2.5.1.46)
mRNA_1830 (10198)
Deoxyhypusine monooxygenase:
an [eIF5A-precursor]-deoxyhypusine + a reduced unknown two electron carrier + dioxygen→an [eIF5A]-hypusine + an oxidized unknown electron carrier + H2O (EC 1.14.99.29)
mRNA_116 (8484)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information