MetaCyc Pathway: streptomycin biosynthesis in Rhodosporidium toruloides IFO0880

Add experiment(s):


Inositol 2-dehydrogenase:
myo-inositol + NAD+→scyllo-inosose + NADH + H+ (EC 1.1.1.18)
No genes
Phosphoglucomutase (in reverse):
D-glucopyranose 6-phosphate→α-D-glucopyranose 1-phosphate (EC 5.4.2.2)
mRNA_1591 (9959)
dTDP-β-L-rhamnose→dTDP-L-dihydrostreptose
No genes
Glutamine--scyllo-inositol transaminase:
scyllo-inosose + L-glutamine→1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate (EC 2.6.1.50)
No genes
Glucose-1-phosphate cytidylyltransferase:
α-D-glucopyranose 1-phosphate + CTP + H+→CDP-α-D-glucose + diphosphate (EC 2.7.7.33)
No genes
CDP-α-D-glucose→CDP-N-methyl-L-glucosamine
No genes
Scyllo-inosamine 4-kinase:
1-amino-1-deoxy-scyllo-inositol + ATP→1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H+ (EC 2.7.1.65)
No genes
Scyllo-inosamine-4-phosphate amidinotransferase:
1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine→1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine (EC 2.1.4.2)
No genes
Guanidinodeoxy-scyllo-inositol-4-phosphatase:
1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O→1-guanidino-1-deoxy-scyllo-inositol + phosphate (EC 3.1.3.40)
No genes
1-guanidino-1-deoxy-scyllo-inositol + an oxidized unknown electron carrier→D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + a reduced unknown two electron carrier
No genes
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase (in reverse):
D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine→D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate (EC 2.6.1.56)
No genes
D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + ATP→N1-amidinostreptamine 6-phosphate + ADP + H+
No genes
N1-amidinostreptamine 6-phosphate + L-arginine→streptidine 6-phosphate + L-ornithine
No genes
dihydrostreptosyltransferase:
dTDP-L-dihydrostreptose + streptidine 6-phosphate→O-1,4-α-L-dihydrostreptosyl-streptidine 6-phosphate + H+ + dTDP (EC 2.4.2.27)
No genes
CDP-N-methyl-L-glucosamine + O-1,4-α-L-dihydrostreptosyl-streptidine 6-phosphate→dihydrostreptomycin 6-phosphate + CDP + H+
No genes
dihydrostreptomycin 6-phosphate + an oxidized unknown electron carrier→streptomycin 6-phosphate + a reduced unknown two electron carrier
No genes
Streptomycin-6-phosphatase:
streptomycin 6-phosphate + H2O→streptomycin + phosphate (EC 3.1.3.39)
No genes
Streptomycin 6-kinase:
streptomycin + ATP→streptomycin 6-phosphate + ADP + H+ (EC 2.7.1.72)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information