MetaCyc Pathway: superpathway of phenylethylamine degradation in Rhodosporidium toruloides IFO0880

Add experiment(s):


Primary-amine oxidase:
2-phenylethylamine + dioxygen + H2O→phenylacetaldehyde + ammonium + hydrogen peroxide
(EC 1.4.3.21)
mRNA_1940 (10308)
mRNA_5591 (13959)
Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD+ + H2O→phenylacetate + NADH + 2 H+
(EC 1.2.1.39)
mRNA_3674 (12042)
Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate
(EC 6.2.1.30)
No genes
phenylacetyl-CoA + NADPH + dioxygen + H+→2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O (EC 1.14.13.149)
No genes
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA→2-oxepin-2(3H)-ylideneacetyl-CoA (EC 5.3.3.18)
No genes
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O→3-oxo-5,6-didehydrosuberyl-CoA semialdehyde (EC 3.3.2.12)
No genes
3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP+ + H2O→3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ (EC 1.2.1.91)
No genes
3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A→trans-2,3-dehydroadipyl-coA + acetyl-CoA (EC 2.3.1.223)
mRNA_5445 (13813)
mRNA_6860 (15228)
Enoyl-CoA hydratase (in reverse):
trans-2,3-dehydroadipyl-coA + H2O→(3S)-hydroxyadipyl-CoA
(EC 4.2.1.17)
mRNA_2742 (11110)
mRNA_3539 (11907)
mRNA_6437 (14805)
mRNA_8147 (16515)
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipyl-CoA + NADH + H+
(EC 1.1.1.35)
mRNA_2835 (11203)
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA
(EC 2.3.1.174)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information