MetaCyc Pathway: gluconeogenesis II (Methanobacterium thermoautotrophicum) in Rhodosporidium toruloides IFO0880

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Carbon-monoxide dehydrogenase (ferredoxin) (in reverse):
CO2 + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→carbon monoxide + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.2.7.4; 2.3.3.M4; 2.3.3.M5)
No genes
CO2 + a methanofuran + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→a formylmethanofuran + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.2.7.12)
No genes
Carbonate dehydratase (in reverse):
CO2 + H2O→hydrogencarbonate + H+ (EC 4.2.1.1)
mRNA_4213 (12581)
mRNA_7775 (16143)
Formylmethanofuran--tetrahydromethanopterin N-formyltransferase:
a formylmethanofuran + tetrahydromethanopterin + H+→5-formyl-tetrahydromethanopterin + a methanofuran (EC 2.3.1.101)
No genes
Methenyltetrahydromethanopterin cyclohydrolase (in reverse):
5-formyl-tetrahydromethanopterin + H+→5,10-methenyltetrahydromethanopterin + H2O (EC 3.5.4.27)
No genes
5,10-methenyltetrahydromethanopterin hydrogenase:
5,10-methenyltetrahydromethanopterin + H2→5,10-methylene-tetrahydromethanopterin + H+ (EC 1.12.98.2)
No genes
5,10-methylene-tetrahydromethanopterin + a reduced factor 420→N5-methyltetrahydromethanopterin + an oxidized factor 420 (EC 1.5.98.2)
No genes
N5-methyltetrahydromethanopterin + a [Co(I) corrinoid Fe-S protein] + H+→tetrahydromethanopterin + a [methyl-Co(III) corrinoid Fe-S protein] (EC 2.1.1.245; 2.3.3.M4)
No genes
CO-methylating acetyl-CoA synthase (in reverse):
carbon monoxide + a [methyl-Co(III) corrinoid Fe-S protein] + coenzyme A→acetyl-CoA + a [Co(I) corrinoid Fe-S protein] + H+ (EC 2.3.1.169; 2.3.3.M4; 2.3.3.M5)
No genes
Pyruvate synthase (in reverse):
acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
No genes
Pyruvate carboxylase:
hydrogencarbonate + pyruvate + ATP→oxaloacetate + ADP + H+ + phosphate (EC 6.4.1.1)
mRNA_8262 (16630)
Phosphopyruvate hydratase (in reverse):
phosphoenolpyruvate + H2O→2-phospho-D-glycerate (EC 4.2.1.11)
mRNA_4451 (12819)
mRNA_8034 (16402)
mRNA_669 (9037)
Phosphoenolpyruvate carboxylase (in reverse):
hydrogencarbonate + phosphoenolpyruvate→oxaloacetate + phosphate (EC 4.1.1.31)
No genes
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
mRNA_2701 (11069)
mRNA_4634 (13002)
2-phospho-D-glycerate→3-phospho-D-glycerate (EC 5.4.2.12)
mRNA_4025 (12393)
mRNA_1542 (9910)
Glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) (in reverse):
3-phospho-D-glycerate + 3 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→D-glyceraldehyde 3-phosphate + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.2.7.6)
No genes
Triose-phosphate isomerase:
D-glyceraldehyde 3-phosphate→glycerone phosphate (EC 5.3.1.1)
mRNA_6808 (15176)
mRNA_7700 (16068)
mRNA_8276 (16644)
mRNA_932 (9300)
Fructose-bisphosphate aldolase (in reverse):
glycerone phosphate + D-glyceraldehyde 3-phosphate→β-D-fructofuranose 1,6-bisphosphate (EC 4.1.2.13)
mRNA_7052 (15420)
ADP-specific phosphofructokinase (in reverse):
β-D-fructofuranose 1,6-bisphosphate + AMP + H+→β-D-fructofuranose 6-phosphate + ADP (EC 2.7.1.146)
No genes
Glucose-6-phosphate isomerase (in reverse):
β-D-fructofuranose 6-phosphate→D-glucopyranose 6-phosphate (EC 5.3.1.9)
mRNA_1221 (9589)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information