Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygen→N-Formyl-L-kynurenine (EC 1.13.11.11; 1.13.11.52) |
| No genes |
Arylformamidase:
N-Formyl-L-kynurenine + H2O→L-kynurenine + formate + H+ (EC 3.5.1.9) |
| No genes |
Kynurenine--oxoglutarate transaminase:
L-kynurenine + 2-oxoglutarate→4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate (EC 2.6.1.7) |
| mRNA_172 (8540) |
Kynureninase:
L-kynurenine + H2O→anthranilate + L-alanine + H+ (EC 3.7.1.3) |
| mRNA_357 (8725) |
Kynurenine 3-monooxygenase:
L-kynurenine + NADPH + dioxygen + H+→3-hydroxy-L-kynurenine + NADP+ + H2O (EC 1.14.13.9) |
| mRNA_899 (9267) |
Kynureninase:
3-hydroxy-L-kynurenine + H2O→3-hydroxyanthranilate + L-alanine + H+ (EC 3.7.1.3) |
| mRNA_357 (8725) |
Kynurenine--glyoxylate transaminase:
4-(2-aminophenyl)-2,4-dioxobutanoate→kynurenate + H+ + H2O (spontaneous) (EC 2.6.1.63; 2.6.1.7) |
| mRNA_172 (8540) |
Kynurenine--oxoglutarate transaminase:
3-hydroxy-L-kynurenine + 2-oxoglutarate→4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate (EC 2.6.1.7) |
| mRNA_172 (8540) |
| anthranilate + FADH2 + dioxygen→3-hydroxyanthranilate + FAD + H+ + H2O (EC 1.14.14.8) |
| No genes |
3-hydroxyanthranilate 3,4-dioxygenase:
3-hydroxyanthranilate + dioxygen→2-amino-3-carboxymuconate-6-semialdehyde (EC 1.13.11.6) |
| mRNA_234 (8602) |
Kynurenine 7,8-hydroxylase:
kynurenate + a reduced unknown two electron carrier + dioxygen→7,8-dihydro-7,8-dihydroxykynurenate + an oxidized unknown electron carrier (EC 1.14.99.2) |
| No genes |
Kynurenine--glyoxylate transaminase:
4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate→xanthurenate + H2O (spontaneous) (EC 2.6.1.63; 2.6.1.7) |
| mRNA_172 (8540) |
Kynurenate-7,8-dihydrodiol dehydrogenase:
7,8-dihydro-7,8-dihydroxykynurenate + NAD+→7,8-dihydroxykynurenate + NADH (EC 1.3.1.18) |
| No genes |
Aminocarboxymuconate-semialdehyde decarboxylase:
2-amino-3-carboxymuconate-6-semialdehyde + H+→(2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + CO2 (EC 4.1.1.45) |
| No genes |
7,8-dihydroxykynurenate 8,8a-dioxygenase:
7,8-dihydroxykynurenate + dioxygen→5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate + H+ (EC 1.13.11.10) |
| No genes |
Aminomuconate-semialdehyde dehydrogenase:
(2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + NAD+ + H2O→(2Z,4E)-2-aminomuconate + NADH + 2 H+ (EC 1.2.1.32) |
| No genes |
| (2Z,4E)-2-amino-6-oxohexa-2,4-dienoate→picolinate + H+ + H2O (spontaneous) |
| No genes |
2-aminomuconate deaminase:
(2Z,4E)-2-aminomuconate + H2O→(3E)-2-oxohex-3-enedioate + ammonium (EC 3.5.99.5) |
| No genes |
| 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate + a reduced unknown two electron carrier→5-(3-carboxy-3-oxopropyl)-4,6-dihydroxypyridine-2-carboxylate + an oxidized unknown electron carrier |
| No genes |
| (3E)-2-oxohex-3-enedioate + NADH + H+→2-oxoadipate + NAD+ |
| No genes |
| 5-(3-carboxy-3-oxopropyl)-4,6-dihydroxypyridine-2-carboxylate + H+→5-(2'-formylethyl)-4,6-dihydroxypicolinate + CO2 |
| No genes |
| 2-oxoadipate + coenzyme A + NAD+→glutaryl-CoA + CO2 + NADH (EC 1.2.1.105) |
| No genes |
| 5-(2'-formylethyl)-4,6-dihydroxypicolinate + NADP+ + H2O→5-(2'-carboxyethyl)-4,6-dihydroxypicolinate + NADPH + 2 H+ |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information