MetaCyc Pathway: serotonin degradation in Rhodosporidium toruloides IFO0880

Add experiment(s):


Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
mRNA_2053 (10421)
mRNA_2289 (10657)
mRNA_2380 (10748)
mRNA_2756 (11124)
mRNA_3674 (12042)
mRNA_3891 (12259)
mRNA_4582 (12950)
mRNA_5058 (13426)
mRNA_7446 (15814)
mRNA_7955 (16323)
mRNA_8468 (16836)
mRNA_324 (8692)
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
mRNA_1661 (10029)
mRNA_1713 (10081)
mRNA_3282 (11650)
mRNA_3297 (11665)
mRNA_3939 (12307)
mRNA_4452 (12820)
mRNA_4507 (12875)
mRNA_5059 (13427)
mRNA_5186 (13554)
mRNA_5194 (13562)
mRNA_5579 (13947)
mRNA_5740 (14108)
mRNA_5741 (14109)
mRNA_7070 (15438)
mRNA_7110 (15478)
mRNA_8149 (16517)
mRNA_733 (9101)
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information