MetaCyc Pathway: salinosporamide A biosynthesis in Rhodosporidium toruloides IFO0880

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Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
mRNA_1336 (9704)
S-adenosyl-L-methionine + chloride→5'-chloro-5'-deoxyadenosine + L-methionine (EC 2.5.1.94)
No genes
Purine-nucleoside phosphorylase:
5'-chloro-5'-deoxyadenosine + phosphate→5-chloro-5-deoxyribose 1-phosphate + adenine (EC 2.4.2.1)
mRNA_7908 (16276)
prephenate + a reduced unknown two electron carrier→dehydroprephenate + an oxidized unknown electron carrier
No genes
5-chloro-5-deoxyribose 1-phosphate + H2O→5-chloro-5-deoxy-D-ribose + phosphate
No genes
dehydroprephenate + H+→3-(cyclohexa-1,3-dien-1-yl)-2-oxopropanoate + CO2 + H2O
No genes
5-chloro-5-deoxy-D-ribose + NAD+→5-chloro-5-deoxy-D-ribono-γ-lactone + NADH + H+
No genes
3-(cyclohexa-1,3-dien-1-yl)-2-oxopropanoate + a reduced unknown two electron carrier→3-[(1S)-cyclohex-3-en-1-yl)]-2-oxopropanoate + an oxidized unknown electron carrier
No genes
5-chloro-5-deoxy-D-ribono-γ-lactone + H2O→5-chloro-5-deoxy-D-ribonate + H+ (spontaneous)
No genes
3-[(1S)-cyclohex-3-en-1-yl)]-2-oxopropanoate + an aminated amino group donor→L-3-cyclohex-2'-enylalanine + a deaminated amino group donor
No genes
5-chloro-5-deoxy-D-ribonate→5-chloro-4-hydroxy-2-oxopentanoate + H2O
No genes
5-chloro-4-hydroxy-2-oxopentanoate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→4-chloro-3-hydroxybutyryl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster
No genes
4-chloro-3-hydroxybutyryl-CoA→4-chloro-crotonyl-CoA + H2O
No genes
4-chloro-crotonyl-CoA + CO2 + NADH→chloroethylmalonyl-CoA + NAD+
No genes
chloroethylmalonyl-CoA + L-3-cyclohex-2'-enylalanine + acetyl-CoA + an oxidized unknown electron carrier + H+→salinosporamide A + CO2 + 2 coenzyme A + a reduced unknown two electron carrier
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information