MetaCyc Pathway: superpathway of quinolone and alkylquinolone biosynthesis in Rhodosporidium toruloides IFO0880

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Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H+ + pyruvate (EC 4.1.3.27)
mRNA_6741 (15109)
octanoyl-CoA + a [PqsC protein]-L-cysteine→a [PqsC protein]-S-octanoyl-L-cysteine + coenzyme A (EC 2.3.1.230)
No genes
Anthranilate--CoA ligase:
anthranilate + ATP + coenzyme A→anthraniloyl-CoA + AMP + diphosphate (EC 6.2.1.32)
No genes
anthraniloyl-CoA + a [PqsD protein]-L-cysteine→a [PqsD protein]-S-anthraniloyl-L-cysteine + coenzyme A (EC 2.3.1.262)
No genes
a [PqsD protein]-S-anthraniloyl-L-cysteine + malonyl-CoA + H+→(2-aminobenzoyl)acetyl-CoA + CO2 + a [PqsD protein]-L-cysteine (EC 2.3.1.262)
No genes
(2-aminobenzoyl)acetyl-CoA + H2O→(2-aminobenzoyl)acetate + coenzyme A + H+ (EC 3.1.2.32)
No genes
(2-aminobenzoyl)acetyl-CoA→4-hydroxyquinolin-2(1H)-one + coenzyme A (spontaneous)
No genes
(2-aminobenzoyl)acetate + a [PqsC protein]-S-octanoyl-L-cysteine + H+→1-(2-aminophenyl)decane-1,3-dione + CO2 + a [PqsC protein]-L-cysteine (EC 2.3.1.230)
No genes
1-(2-aminophenyl)decane-1,3-dione→2-heptyl-4-quinolone + H2O (EC 2.3.1.230)
No genes
2-heptyl-4-quinolone + NADH + dioxygen + H+→2-heptyl-3-hydroxy-4-quinolone + NAD+ + H2O (EC 1.14.13.182)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information