Acetyl-CoA carboxylase:
acetyl-CoA + ATP + hydrogencarbonate→malonyl-CoA + ADP + H+ + phosphate (EC 6.4.1.2) |
| mRNA_271 (8639) |
| acetyl-CoA + 9 malonyl-CoA + 8 H+ + H2O→3,5,7,9,11,13,15,17,19-nonaoxoicosanoate + 9 CO2 + 10 coenzyme A (EC 2.3.1.235) |
| No genes |
| 3,5,7,9,11,13,15,17,19-nonaoxoicosanoate + 3 NADPH + dioxygen + 4 H+→UWM6 + CO2 + 3 NADP+ + 5 H2O |
| No genes |
| UWM6→prejadomycin + H2O |
| No genes |
| prejadomycin + NAD(P)H + dioxygen + H+→8-methyltetraphene-1,5,6,11,12-pentol + NAD(P)+ + 2 H2O |
| No genes |
| 8-methyltetraphene-1,5,6,11,12-pentol + dioxygen→dehydrorabelomycin + hydrogen peroxide (spontaneous) |
| No genes |
| dehydrorabelomycin + dioxygen→3-(2-formyl-6-hydroxy-4-methylphenyl)-8-hydroxy-1,4-dioxonaphthalene-2-carboxylate + H+ |
| No genes |
| 3-(2-formyl-6-hydroxy-4-methylphenyl)-8-hydroxy-1,4-dioxonaphthalene-2-carboxylate + L-isoleucine→(3aS)-jadomycin A + CO2 + H2O (spontaneous) |
| No genes |
| (3aS)-jadomycin A + dTDP-β-L-digitoxose→(3aS)-jadomycin B + H+ + dTDP |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information