MetaCyc Pathway: icosapentaenoate biosynthesis II (6-desaturase, mammals) in Rhodosporidium toruloides IFO0880

Add experiment(s):


Long-chain-fatty-acid--CoA ligase:
α-linolenate + ATP + coenzyme A→α-linolenoyl-CoA + AMP + diphosphate
(EC 6.2.1.3)
mRNA_4187 (12555)
mRNA_7380 (15748)
Linoleoyl-CoA desaturase:
α-linolenoyl-CoA + 2 a ferrocytochrome b5 + dioxygen + 2 H+→stearidonoyl-CoA + 2 a ferricytochrome b5 + 2 H2O
(EC 1.14.19.3)
mRNA_1210 (9578)
stearidonoyl-CoA + malonyl-CoA + H+→(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + coenzyme A
No genes
(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + NAD(P)H + H+→(3R,8Z,11Z,14Z,17Z)-3-hydroxyicosatetraenoyl-CoA + NAD(P)+ (EC 1.1.1.330)
No genes
(3R,8Z,11Z,14Z,17Z)-3-hydroxyicosatetraenoyl-CoA→(2E,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA + H2O (EC 4.2.1.134)
No genes
(2E,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA + a reduced unknown two electron carrier→(8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA + an oxidized unknown electron carrier (EC 1.3.1.93)
No genes
(8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA + 2 a ferrocytochrome b5 + dioxygen + 2 H+→(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA + 2 a ferricytochrome b5 + 2 H2O (EC 1.14.19.44)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information