Glucose-1-phosphate thymidylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + dTTP→dTDP-α-D-glucose + diphosphate (EC 2.7.7.24) |
| No genes |
6-deoxyerythronolide-B synthase:
propanoyl-CoA + 6 (S)-methylmalonyl-CoA + 6 NADPH + 12 H+→6-deoxyerythronolide B + 6 CO2 + 7 coenzyme A + 6 NADP+ + H2O (EC 2.3.1.94) |
| No genes |
dTDP-glucose 4,6-dehydratase:
dTDP-α-D-glucose→dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H2O (EC 4.2.1.46) |
| mRNA_7050 (15418) |
| 6-deoxyerythronolide B + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→erythronolide B + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.14.15.35) |
| No genes |
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase (in reverse):
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + L-glutamate→dTDP-viosamine + 2-oxoglutarate (EC 2.6.1.33) |
| No genes |
| dTDP-4-dehydro-6-deoxy-α-D-glucopyranose→dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H+ + H2O (EC 4.2.1.159) |
| No genes |
| dTDP-viosamine + a reduced unknown two electron carrier + S-adenosyl-L-methionine→dTDP-3-dehydro-4,6-deoxy-α-D-glucose + ammonium + an oxidized unknown electron carrier + 5'-deoxyadenosine + L-methionine + H+ (EC 4.3.1.30) |
| No genes |
| dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + NAD(P)H + 2 H+→dTDP-4-dehydro-2,6-dideoxy-α-D-allose + NAD(P)+ |
| No genes |
| dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H+→dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose (spontaneous) (EC 4.2.1.159) |
| No genes |
| dTDP-3-dehydro-4,6-deoxy-α-D-glucose + L-glutamate→dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose + 2-oxoglutarate (EC 2.6.1.106) |
| No genes |
| dTDP-4-dehydro-2,6-dideoxy-α-D-allose + S-adenosyl-L-methionine→dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-allose + S-adenosyl-L-homocysteine + H+ |
| No genes |
| dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose + L-glutamate→dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose + 2-oxoglutarate |
| No genes |
| dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose + 2 S-adenosyl-L-methionine→dTDP-D-desosamine + 2 S-adenosyl-L-homocysteine + 2 H+ (EC 2.1.1.234) |
| No genes |
| dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-allose→dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-galactose |
| No genes |
| dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose + 2 S-adenosyl-L-methionine→dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose + 2 S-adenosyl-L-homocysteine + 2 H+ |
| No genes |
| dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-galactose + NADPH + H+→dTDP-β-L-mycarose + NADP+ |
| No genes |
| dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose→dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-β-L-glucose |
| No genes |
| erythronolide B + dTDP-β-L-mycarose→3-α-mycarosylerythronolide B + H+ + dTDP (EC 2.4.1.328) |
| No genes |
| dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-β-L-glucose + NADPH + H+→dTDP-β-L-megosamine + NADP+ |
| No genes |
| dTDP-D-desosamine + 3-α-mycarosylerythronolide B→erythromycin D + H+ + dTDP (EC 2.4.1.278) |
| No genes |
| erythromycin D + NADPH + dioxygen + H+→erythromycin C + NADP+ + H2O (EC 1.14.13.154) |
| No genes |
| erythromycin C + dTDP-β-L-megosamine→megalomicin A + H+ + dTDP |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information