MetaCyc Pathway: superpathway of scopolin and esculin biosynthesis in Rhodosporidium toruloides IFO0880

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Phenylalanine ammonia-lyase:
L-phenylalanine→cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
mRNA_8094 (16462)
cinnamate + dioxygen + a reduced [NADPH-hemoprotein reductase]→4-coumarate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.91)
No genes
4-coumarate + dioxygen + a reduced [NADPH-hemoprotein reductase]→trans-caffeate + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.96)
No genes
1.-.-.-:
4-coumarate→2,4-dihydroxycinnamate
No genes
Caffeate O-methyltransferase:
trans-caffeate + S-adenosyl-L-methionine→ferulate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.68)
No genes
2,4-dihydroxycinnamate→(Z)-3-(2,4-dihydroxyphenyl)-prop-2-enoate
No genes
ferulate + 2-oxoglutarate + dioxygen→(E)-6'-hydroxyferulate + CO2 + succinate
No genes
(Z)-3-(2,4-dihydroxyphenyl)-prop-2-enoate→umbelliferone
No genes
(E)-6'-hydroxyferulate→(Z)-6'-hydroxyferulate
No genes
umbelliferone→esculetin
No genes
esculetin + D-glucopyranose→esculin + H2O
No genes
esculetin + S-adenosyl-L-methionine→scopoletin + S-adenosyl-L-homocysteine + H+
No genes
(Z)-6'-hydroxyferulate→scopoletin
No genes
Scopoletin glucosyltransferase:
scopoletin + UDP-α-D-glucose→scopolin + UDP + H+ (EC 2.4.1.128)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information