MetaCyc Pathway: novobiocin biosynthesis in Rhodosporidium toruloides IFO0880

Add experiment(s):


Glucose-1-phosphate thymidylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + dTTP→dTDP-α-D-glucose + diphosphate (EC 2.7.7.24)
No genes
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
mRNA_7857 (16225)
L-tyrosine + ATP + a NovH peptidyl-carrier protein→L-tyrosine-S-[NovH protein] + AMP + diphosphate
No genes
dTDP-glucose 4,6-dehydratase:
dTDP-α-D-glucose→dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H2O (EC 4.2.1.46)
mRNA_7050 (15418)
3-(4-hydroxyphenyl)pyruvate + prenyl diphosphate→(4-hydroxy-3-prenylphenyl)pyruvate + diphosphate (EC 2.5.1.111)
No genes
L-tyrosine-S-[NovH protein] + NADPH + dioxygen + H+→(R)-β-hydroxy-L-tyrosine-S-[NovH protein] + NADP+ + H2O
No genes
dTDP-4-dehydrorhamnose 3,5-epimerase:
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose→dTDP-4-dehydro-β-L-rhamnose (EC 5.1.3.13)
No genes
(R)-β-hydroxy-L-tyrosine-S-[NovH protein] + NADP+→β-oxo-L-tyrosine-S-[NovH protein] + NADPH + H+
No genes
(4-hydroxy-3-prenylphenyl)pyruvate + dioxygen→4-hydroxy-3-prenylmandelate + CO2 (EC 1.13.11.83)
No genes
β-oxo-L-tyrosine-S-[NovH protein] + NADPH + dioxygen + H+→2'-hydroxy-β-oxo-L-tyrosine-S-[NovH protein] + NADP+ + H2O
No genes
dTDP-4-dehydro-β-L-rhamnose + S-adenosyl-L-methionine→dTDP-4-dehydro-5-methyl-β-L-rhamnose + S-adenosyl-L-homocysteine + H+
No genes
4-hydroxy-3-prenylmandelate + dioxygen→4-hydroxy-3-prenylbenzoate + CO2 + H2O (EC 1.13.12.23)
No genes
2'-hydroxy-β-oxo-L-tyrosine-S-[NovH protein]→3-amino-4,7-dihydroxycoumarin + a NovH peptidyl-carrier protein + H+
No genes
dTDP-4-dehydro-5-methyl-β-L-rhamnose + NADH + H+→dTDP-4-O-demethyl-β-L-noviose + NAD+
No genes
3-amino-4,7-dihydroxycoumarin + 4-hydroxy-3-prenylbenzoate + ATP→8-demethylnovobiocic acid + AMP + diphosphate + H+ (EC 6.3.1.15)
No genes
8-demethylnovobiocic acid + S-adenosyl-L-methionine→novobiocic acid + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.284)
No genes
novobiocic acid + dTDP-4-O-demethyl-β-L-noviose→demethyldecarbamoyl novobiocin + H+ + dTDP (EC 2.4.1.302)
No genes
demethyldecarbamoyl novobiocin + S-adenosyl-L-methionine→decarbamoylnovobiocin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.285)
No genes
decarbamoylnovobiocin + carbamoyl phosphate→novobiocin + phosphate (EC 2.1.3.12)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information